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Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis

Acupuncture therapy (AT) is a widely used, alternative medicine in China. AT is an effective treatment for many diseases, but its efficacy in stable chronic obstructive pulmonary disease (COPD) remains controversial. Therefore, we performed the present meta-analysis to evaluate the efficacy of AT in...

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Autores principales: Fan, Su, Zhang, Zhenyu, Wang, Qinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101258/
https://www.ncbi.nlm.nih.gov/pubmed/37058051
http://dx.doi.org/10.1097/MD.0000000000033537
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author Fan, Su
Zhang, Zhenyu
Wang, Qinglin
author_facet Fan, Su
Zhang, Zhenyu
Wang, Qinglin
author_sort Fan, Su
collection PubMed
description Acupuncture therapy (AT) is a widely used, alternative medicine in China. AT is an effective treatment for many diseases, but its efficacy in stable chronic obstructive pulmonary disease (COPD) remains controversial. Therefore, we performed the present meta-analysis to evaluate the efficacy of AT in stable COPD patients. METHODS: Randomized controlled trials (RCTs) for AT efficacy in stable COPD patients were searched in literature databases from the inception to December 31, 2021. Pooled effect sizes of outcome measurements with respect to lung function (forced vital capacity [FVC], forced expiratory volume in 1 second [FEV(1)], FEV(1) in predicted value [FEV(1)%], FEV(1)/FVC), quality of life (St. George respiratory questionnaire [SGRQ]), exercise capacity (6-minute walking distance [6MWD]) and effective rate were estimated by calculating weighted mean difference (WMD) or odds ratio (OR) with corresponding 95% confidence interval (95% CI), respectively, by a random-effect model. RESULTS: A total of 28 RCTs with 2130 COPD patients were included. AT group had significant improvement in FVC (WMD = 0.29 L, 95% CI: 0.22–0.36, P < .001), FEV(1) (WMD = 0.33 L, 95% CI: 0.23–0.43, P < .001), FEV(1)% (WMD = 3.30%, 95% CI: 3.30–4.64, P < .001), FEV(1)/FVC (WMD = 5.45%, 95% CI: 4.41–6.49, P < .001), 6MWD (WMD = 45.48 m, 95% CI: 28.21–62.16, P < .001), SGRQ (WMD = −7.79, 95% CI: −12.34 to −3.24, P < .001), and a higher effective rate (OR = 3.71, 95% CI: 2.50–5.52, P < .001) compared to the control group. Subgroup analysis stratified by comparison model (AT combined with other treatments vs other treatments, AT alone vs sham AT) and treatment duration (≥8 weeks, <8 weeks) also showed more improvement in AT arm than control arm without significant between-subgroup difference. Adverse events were reported in a few studies and only mild reactions were observed. CONCLUSION: AT is effective in improving lung function, quality of life and exercise capacity, and can be used as an adjunctive treatment in patients with stable COPD.
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spelling pubmed-101012582023-04-14 Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis Fan, Su Zhang, Zhenyu Wang, Qinglin Medicine (Baltimore) 3800 Acupuncture therapy (AT) is a widely used, alternative medicine in China. AT is an effective treatment for many diseases, but its efficacy in stable chronic obstructive pulmonary disease (COPD) remains controversial. Therefore, we performed the present meta-analysis to evaluate the efficacy of AT in stable COPD patients. METHODS: Randomized controlled trials (RCTs) for AT efficacy in stable COPD patients were searched in literature databases from the inception to December 31, 2021. Pooled effect sizes of outcome measurements with respect to lung function (forced vital capacity [FVC], forced expiratory volume in 1 second [FEV(1)], FEV(1) in predicted value [FEV(1)%], FEV(1)/FVC), quality of life (St. George respiratory questionnaire [SGRQ]), exercise capacity (6-minute walking distance [6MWD]) and effective rate were estimated by calculating weighted mean difference (WMD) or odds ratio (OR) with corresponding 95% confidence interval (95% CI), respectively, by a random-effect model. RESULTS: A total of 28 RCTs with 2130 COPD patients were included. AT group had significant improvement in FVC (WMD = 0.29 L, 95% CI: 0.22–0.36, P < .001), FEV(1) (WMD = 0.33 L, 95% CI: 0.23–0.43, P < .001), FEV(1)% (WMD = 3.30%, 95% CI: 3.30–4.64, P < .001), FEV(1)/FVC (WMD = 5.45%, 95% CI: 4.41–6.49, P < .001), 6MWD (WMD = 45.48 m, 95% CI: 28.21–62.16, P < .001), SGRQ (WMD = −7.79, 95% CI: −12.34 to −3.24, P < .001), and a higher effective rate (OR = 3.71, 95% CI: 2.50–5.52, P < .001) compared to the control group. Subgroup analysis stratified by comparison model (AT combined with other treatments vs other treatments, AT alone vs sham AT) and treatment duration (≥8 weeks, <8 weeks) also showed more improvement in AT arm than control arm without significant between-subgroup difference. Adverse events were reported in a few studies and only mild reactions were observed. CONCLUSION: AT is effective in improving lung function, quality of life and exercise capacity, and can be used as an adjunctive treatment in patients with stable COPD. Lippincott Williams & Wilkins 2023-04-14 /pmc/articles/PMC10101258/ /pubmed/37058051 http://dx.doi.org/10.1097/MD.0000000000033537 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 3800
Fan, Su
Zhang, Zhenyu
Wang, Qinglin
Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
title Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_full Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_fullStr Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_full_unstemmed Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_short Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_sort efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
topic 3800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101258/
https://www.ncbi.nlm.nih.gov/pubmed/37058051
http://dx.doi.org/10.1097/MD.0000000000033537
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