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Structural and functional activities of brain in patients with vascular cognitive impairment: A case-controlled magnetic resonance imaging study
This study aimed to identify abnormal brain regions and imaging indices of vascular cognitive impairment (VCI) and explore specific imaging diagnostic markers of VCI. In this study, 24 patients with VCI were allocated to the VCI group and 25 healthy subjects were assigned to the healthy control (HC)...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101273/ https://www.ncbi.nlm.nih.gov/pubmed/37058059 http://dx.doi.org/10.1097/MD.0000000000033534 |
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author | Cai, Li-Na Yue, Jinhuan Cao, Dan-Na Wang, Peng Zhang, Qinhong Li, Ang Zhao, Wei-Wei Yang, Guanhu Wang, Yang Peng, Cai-Liang Han, Sheng-Wang Hou, Yu Li, Xiao-Ling |
author_facet | Cai, Li-Na Yue, Jinhuan Cao, Dan-Na Wang, Peng Zhang, Qinhong Li, Ang Zhao, Wei-Wei Yang, Guanhu Wang, Yang Peng, Cai-Liang Han, Sheng-Wang Hou, Yu Li, Xiao-Ling |
author_sort | Cai, Li-Na |
collection | PubMed |
description | This study aimed to identify abnormal brain regions and imaging indices of vascular cognitive impairment (VCI) and explore specific imaging diagnostic markers of VCI. In this study, 24 patients with VCI were allocated to the VCI group and 25 healthy subjects were assigned to the healthy control (HC) group. Demographic data and neuropsychological test scores were compared using SPSS 25.0. The structural and functional imaging data were post-processed and statistically analyzed using CAT12, DPARSF and SPM12 software, based on the MATLAB platform. The structural and functional indices of gray matter volume (GMV) and regional homogeneity (ReHo) were obtained, and inter-group data were analyzed using an independent-sample t test. Sex, age, years of education, and total brain volume were used as covariates. Compared to the HC group, the GMV of VCI in the VCI group decreased significantly in the rectus muscles of the bilateral gyrus, left superior temporal gyrus, left supplementary motor area (SMA), right insula, right superior temporal gyrus, right anterior cuneiform lobe, and right anterior central gyrus (PRECG) (P < .05, FWE correction), without GMV enlargement in the brain area. ReHo decreased in the right inferior temporal gyrus (ITG), right parahippocampal gyrus, and left temporal pole (middle temporal gyrus, right lingual gyrus, left posterior central gyrus, and right middle temporal gyrus), the areas of increased ReHo were the left caudate nucleus, left rectus gyrus, right anterior cingulate gyrus and lateral cingulate gyrus (P < .05, FWE correction). Correlation analysis showed that the GMV of the left superior temporal gyrus was positively correlated with the Montreal Cognitive Assessment (MoCA) score (P < .05), and the GMV of the right insula was positively correlated with the MESE and long delayed memory scores (P < .05). There was a significant positive correlation between the ReHo and short-term delayed memory scores in the middle temporal gyrus of the left temporal pole (P < .05). The volume of GMV and ReHo decreased in VCI patients, suggesting that impairment of brain structure and function in specific regions is the central mechanism of cognitive impairment in these patients. Meanwhile, the functional indices of some brain regions were increased, which may be a compensatory mechanism for the cognitive impairment associated with VCI. |
format | Online Article Text |
id | pubmed-10101273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-101012732023-04-14 Structural and functional activities of brain in patients with vascular cognitive impairment: A case-controlled magnetic resonance imaging study Cai, Li-Na Yue, Jinhuan Cao, Dan-Na Wang, Peng Zhang, Qinhong Li, Ang Zhao, Wei-Wei Yang, Guanhu Wang, Yang Peng, Cai-Liang Han, Sheng-Wang Hou, Yu Li, Xiao-Ling Medicine (Baltimore) 3800 This study aimed to identify abnormal brain regions and imaging indices of vascular cognitive impairment (VCI) and explore specific imaging diagnostic markers of VCI. In this study, 24 patients with VCI were allocated to the VCI group and 25 healthy subjects were assigned to the healthy control (HC) group. Demographic data and neuropsychological test scores were compared using SPSS 25.0. The structural and functional imaging data were post-processed and statistically analyzed using CAT12, DPARSF and SPM12 software, based on the MATLAB platform. The structural and functional indices of gray matter volume (GMV) and regional homogeneity (ReHo) were obtained, and inter-group data were analyzed using an independent-sample t test. Sex, age, years of education, and total brain volume were used as covariates. Compared to the HC group, the GMV of VCI in the VCI group decreased significantly in the rectus muscles of the bilateral gyrus, left superior temporal gyrus, left supplementary motor area (SMA), right insula, right superior temporal gyrus, right anterior cuneiform lobe, and right anterior central gyrus (PRECG) (P < .05, FWE correction), without GMV enlargement in the brain area. ReHo decreased in the right inferior temporal gyrus (ITG), right parahippocampal gyrus, and left temporal pole (middle temporal gyrus, right lingual gyrus, left posterior central gyrus, and right middle temporal gyrus), the areas of increased ReHo were the left caudate nucleus, left rectus gyrus, right anterior cingulate gyrus and lateral cingulate gyrus (P < .05, FWE correction). Correlation analysis showed that the GMV of the left superior temporal gyrus was positively correlated with the Montreal Cognitive Assessment (MoCA) score (P < .05), and the GMV of the right insula was positively correlated with the MESE and long delayed memory scores (P < .05). There was a significant positive correlation between the ReHo and short-term delayed memory scores in the middle temporal gyrus of the left temporal pole (P < .05). The volume of GMV and ReHo decreased in VCI patients, suggesting that impairment of brain structure and function in specific regions is the central mechanism of cognitive impairment in these patients. Meanwhile, the functional indices of some brain regions were increased, which may be a compensatory mechanism for the cognitive impairment associated with VCI. Lippincott Williams & Wilkins 2023-04-14 /pmc/articles/PMC10101273/ /pubmed/37058059 http://dx.doi.org/10.1097/MD.0000000000033534 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 3800 Cai, Li-Na Yue, Jinhuan Cao, Dan-Na Wang, Peng Zhang, Qinhong Li, Ang Zhao, Wei-Wei Yang, Guanhu Wang, Yang Peng, Cai-Liang Han, Sheng-Wang Hou, Yu Li, Xiao-Ling Structural and functional activities of brain in patients with vascular cognitive impairment: A case-controlled magnetic resonance imaging study |
title | Structural and functional activities of brain in patients with vascular cognitive impairment: A case-controlled magnetic resonance imaging study |
title_full | Structural and functional activities of brain in patients with vascular cognitive impairment: A case-controlled magnetic resonance imaging study |
title_fullStr | Structural and functional activities of brain in patients with vascular cognitive impairment: A case-controlled magnetic resonance imaging study |
title_full_unstemmed | Structural and functional activities of brain in patients with vascular cognitive impairment: A case-controlled magnetic resonance imaging study |
title_short | Structural and functional activities of brain in patients with vascular cognitive impairment: A case-controlled magnetic resonance imaging study |
title_sort | structural and functional activities of brain in patients with vascular cognitive impairment: a case-controlled magnetic resonance imaging study |
topic | 3800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101273/ https://www.ncbi.nlm.nih.gov/pubmed/37058059 http://dx.doi.org/10.1097/MD.0000000000033534 |
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