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mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic

The advent of mRNA vaccines represents a significant advance in the field of vaccinology. While several vaccine approaches (mRNA, DNA, recombinant protein, and viral-vectored vaccines) had been investigated at the start of the COVID-19 pandemic, mRNA vaccines quickly gained popularity due to superio...

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Detalles Bibliográficos
Autores principales: Xu, Ziyang, Fisher, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101324/
https://www.ncbi.nlm.nih.gov/pubmed/37063845
http://dx.doi.org/10.3389/fimmu.2023.1155728
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author Xu, Ziyang
Fisher, David E.
author_facet Xu, Ziyang
Fisher, David E.
author_sort Xu, Ziyang
collection PubMed
description The advent of mRNA vaccines represents a significant advance in the field of vaccinology. While several vaccine approaches (mRNA, DNA, recombinant protein, and viral-vectored vaccines) had been investigated at the start of the COVID-19 pandemic, mRNA vaccines quickly gained popularity due to superior immunogenicity at a low dose, strong safety/tolerability profiles, and the possibility of rapid vaccine mass manufacturing and deployment to rural regions. In addition to inducing protective neutralizing antibody responses, mRNA vaccines can also elicit high-magnitude cytotoxic T-cell responses comparable to natural viral infections; thereby, drawing significant interest from cancer immunotherapy experts. This mini-review will highlight key developmental milestones and lessons we have learned from mRNA vaccines during the COVID-19 pandemic, with a specific emphasis on clinical trial data gathered so far for mRNA vaccines against melanoma and other forms of cancer.
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spelling pubmed-101013242023-04-14 mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic Xu, Ziyang Fisher, David E. Front Immunol Immunology The advent of mRNA vaccines represents a significant advance in the field of vaccinology. While several vaccine approaches (mRNA, DNA, recombinant protein, and viral-vectored vaccines) had been investigated at the start of the COVID-19 pandemic, mRNA vaccines quickly gained popularity due to superior immunogenicity at a low dose, strong safety/tolerability profiles, and the possibility of rapid vaccine mass manufacturing and deployment to rural regions. In addition to inducing protective neutralizing antibody responses, mRNA vaccines can also elicit high-magnitude cytotoxic T-cell responses comparable to natural viral infections; thereby, drawing significant interest from cancer immunotherapy experts. This mini-review will highlight key developmental milestones and lessons we have learned from mRNA vaccines during the COVID-19 pandemic, with a specific emphasis on clinical trial data gathered so far for mRNA vaccines against melanoma and other forms of cancer. Frontiers Media S.A. 2023-03-30 /pmc/articles/PMC10101324/ /pubmed/37063845 http://dx.doi.org/10.3389/fimmu.2023.1155728 Text en Copyright © 2023 Xu and Fisher https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xu, Ziyang
Fisher, David E.
mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic
title mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic
title_full mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic
title_fullStr mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic
title_full_unstemmed mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic
title_short mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic
title_sort mrna melanoma vaccine revolution spurred by the covid-19 pandemic
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101324/
https://www.ncbi.nlm.nih.gov/pubmed/37063845
http://dx.doi.org/10.3389/fimmu.2023.1155728
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