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Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension

Introduction We aimed to assess renin, aldosterone, and cortisol in the early stages of pregnancy-induced hypertension (PIH), i. e., at the time of diagnosis. Methods During the postural test, we measured aldosterone, renin [Liason DiaSorin Inc. (Italy)], as well as cortisol, sodium, potassium, and...

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Autores principales: Lewandowski, Krzysztof C, Tadros-Zins, Monika, Horzelski, Wojciech, Krekora, Michał, Lewinski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101736/
https://www.ncbi.nlm.nih.gov/pubmed/36807213
http://dx.doi.org/10.1055/a-2025-0510
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author Lewandowski, Krzysztof C
Tadros-Zins, Monika
Horzelski, Wojciech
Krekora, Michał
Lewinski, Andrzej
author_facet Lewandowski, Krzysztof C
Tadros-Zins, Monika
Horzelski, Wojciech
Krekora, Michał
Lewinski, Andrzej
author_sort Lewandowski, Krzysztof C
collection PubMed
description Introduction We aimed to assess renin, aldosterone, and cortisol in the early stages of pregnancy-induced hypertension (PIH), i. e., at the time of diagnosis. Methods During the postural test, we measured aldosterone, renin [Liason DiaSorin Inc. (Italy)], as well as cortisol, sodium, potassium, and 24-h urinary sodium and potassium excretion in 62 women with newly diagnosed PIH, 70 healthy women during the 3rd trimester of pregnancy, and in 22 healthy non-pregnant women. Results In all groups, there was a significant increase in aldosterone and renin in upright versus supine posture (p<0.01). Both supine and upright aldosterone concentrations were higher in healthy pregnant women than in women with PIH and the lowest in healthy not-pregnant [supine (median±intequartile range): 25.04±18.4 ng/dL, 18.03±12.58 ng/dL, and 7.48±4.78 ng/dL, p<0.001, upright: 31.60±21.32 ng/dL, 25.11±13.15 ng/dL, and 12.4±12.4 ng/dL, p<0.001, for healthy pregnant, pregnant with PIH, and non-pregnant, respectively]. Supine renin concentrations were higher only in healthy pregnant (p<0.001), while in the upright position, there was a difference only between healthy pregnant and women with PIH (p=0.002). Both in supine and upright positions, there was no difference in the aldosterone-to-renin ratio between healthy pregnant women and women with PIH, though, in both groups, the ratio was higher than in non-pregnant women (p<0.001). Morning cortisol concentrations and 24-h urinary sodium excretion were lower in women with PIH than in healthy pregnant (p<0.001, p=0.002, respectively). Conclusion Hyperaldosteronism is not involved in the etiology of PIH. In PIH, there is also a tendency towards lower sodium excretion and lower morning cortisol concentrations.
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spelling pubmed-101017362023-04-14 Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension Lewandowski, Krzysztof C Tadros-Zins, Monika Horzelski, Wojciech Krekora, Michał Lewinski, Andrzej Exp Clin Endocrinol Diabetes Introduction We aimed to assess renin, aldosterone, and cortisol in the early stages of pregnancy-induced hypertension (PIH), i. e., at the time of diagnosis. Methods During the postural test, we measured aldosterone, renin [Liason DiaSorin Inc. (Italy)], as well as cortisol, sodium, potassium, and 24-h urinary sodium and potassium excretion in 62 women with newly diagnosed PIH, 70 healthy women during the 3rd trimester of pregnancy, and in 22 healthy non-pregnant women. Results In all groups, there was a significant increase in aldosterone and renin in upright versus supine posture (p<0.01). Both supine and upright aldosterone concentrations were higher in healthy pregnant women than in women with PIH and the lowest in healthy not-pregnant [supine (median±intequartile range): 25.04±18.4 ng/dL, 18.03±12.58 ng/dL, and 7.48±4.78 ng/dL, p<0.001, upright: 31.60±21.32 ng/dL, 25.11±13.15 ng/dL, and 12.4±12.4 ng/dL, p<0.001, for healthy pregnant, pregnant with PIH, and non-pregnant, respectively]. Supine renin concentrations were higher only in healthy pregnant (p<0.001), while in the upright position, there was a difference only between healthy pregnant and women with PIH (p=0.002). Both in supine and upright positions, there was no difference in the aldosterone-to-renin ratio between healthy pregnant women and women with PIH, though, in both groups, the ratio was higher than in non-pregnant women (p<0.001). Morning cortisol concentrations and 24-h urinary sodium excretion were lower in women with PIH than in healthy pregnant (p<0.001, p=0.002, respectively). Conclusion Hyperaldosteronism is not involved in the etiology of PIH. In PIH, there is also a tendency towards lower sodium excretion and lower morning cortisol concentrations. Georg Thieme Verlag KG 2023-02-20 /pmc/articles/PMC10101736/ /pubmed/36807213 http://dx.doi.org/10.1055/a-2025-0510 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Lewandowski, Krzysztof C
Tadros-Zins, Monika
Horzelski, Wojciech
Krekora, Michał
Lewinski, Andrzej
Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension
title Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension
title_full Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension
title_fullStr Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension
title_full_unstemmed Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension
title_short Renin, Aldosterone, and Cortisol in Pregnancy-Induced Hypertension
title_sort renin, aldosterone, and cortisol in pregnancy-induced hypertension
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101736/
https://www.ncbi.nlm.nih.gov/pubmed/36807213
http://dx.doi.org/10.1055/a-2025-0510
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