Priming a vascular-selective cytokine response permits CD8(+) T-cell entry into tumors

Targeting DNA methyltransferase 1 (DNMT1) has immunomodulatory and anti-neoplastic activity, especially when paired with cancer immunotherapies. Here we explore the immunoregulatory functions of DNMT1 in the tumor vasculature of female mice. Dnmt1 deletion in endothelial cells (ECs) impairs tumor gr...

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Detalles Bibliográficos
Autores principales: Kim, Dae Joong, Anandh, Swetha, Null, Jamie L., Przanowski, Piotr, Bhatnagar, Sanchita, Kumar, Pankaj, Shelton, Sarah E., Grundy, Erin E., Chiappinelli, Katherine B., Kamm, Roger D., Barbie, David A., Dudley, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101959/
https://www.ncbi.nlm.nih.gov/pubmed/37055433
http://dx.doi.org/10.1038/s41467-023-37807-z

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