Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

Little is known about the mechanistic significance of the ubiquitin proteasome system (UPS) in a kidney autoimmune environment. In membranous nephropathy (MN), autoantibodies target podocytes of the glomerular filter resulting in proteinuria. Converging biochemical, structural, mouse pathomechanisti...

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Detalles Bibliográficos
Autores principales: Reichelt, Julia, Sachs, Wiebke, Frömbling, Sarah, Fehlert, Julia, Studencka-Turski, Maja, Betz, Anna, Loreth, Desiree, Blume, Lukas, Witt, Susanne, Pohl, Sandra, Brand, Johannes, Czesla, Maire, Knop, Jan, Florea, Bogdan I., Zielinski, Stephanie, Sachs, Marlies, Hoxha, Elion, Hermans-Borgmeyer, Irm, Zahner, Gunther, Wiech, Thorsten, Krüger, Elke, Meyer-Schwesinger, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102022/
https://www.ncbi.nlm.nih.gov/pubmed/37055432
http://dx.doi.org/10.1038/s41467-023-37836-8

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