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Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state

Activation of HER2/ErbB2 coincides with escape from ductal carcinoma in situ (DCIS) premalignancy and disrupts 3D organization of cultured breast-epithelial spheroids. The 3D phenotype is infrequent, however, and mechanisms for its incomplete penetrance have been elusive. Using inducible HER2/ErbB2–...

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Detalles Bibliográficos
Autores principales:	Wang, Lixin, Paudel, B. Bishal, McKnight, R. Anthony, Janes, Kevin A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102026/ https://www.ncbi.nlm.nih.gov/pubmed/37055441 http://dx.doi.org/10.1038/s41467-023-37914-x

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