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Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia

Studies of primary visual cortex have furthered our understanding of amblyopia, long-lasting visual impairment caused by imbalanced input from the two eyes during childhood, which is commonly treated by patching the dominant eye. However, the relative impacts of monocular vs. binocular visual experi...

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Autores principales: Martinez, Jessy D., Donnelly, Marcus J., Popke, Donald S., Torres, Daniel, Wilson, Lydia G., Brancaleone, William P., Sheskey, Sarah, Lin, Cheng-mao, Clawson, Brittany C., Jiang, Sha, Aton, Sara J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102075/
https://www.ncbi.nlm.nih.gov/pubmed/37055505
http://dx.doi.org/10.1038/s42003-023-04798-y
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author Martinez, Jessy D.
Donnelly, Marcus J.
Popke, Donald S.
Torres, Daniel
Wilson, Lydia G.
Brancaleone, William P.
Sheskey, Sarah
Lin, Cheng-mao
Clawson, Brittany C.
Jiang, Sha
Aton, Sara J.
author_facet Martinez, Jessy D.
Donnelly, Marcus J.
Popke, Donald S.
Torres, Daniel
Wilson, Lydia G.
Brancaleone, William P.
Sheskey, Sarah
Lin, Cheng-mao
Clawson, Brittany C.
Jiang, Sha
Aton, Sara J.
author_sort Martinez, Jessy D.
collection PubMed
description Studies of primary visual cortex have furthered our understanding of amblyopia, long-lasting visual impairment caused by imbalanced input from the two eyes during childhood, which is commonly treated by patching the dominant eye. However, the relative impacts of monocular vs. binocular visual experiences on recovery from amblyopia are unclear. Moreover, while sleep promotes visual cortex plasticity following loss of input from one eye, its role in recovering binocular visual function is unknown. Using monocular deprivation in juvenile male mice to model amblyopia, we compared recovery of cortical neurons’ visual responses after identical-duration, identical-quality binocular or monocular visual experiences. We demonstrate that binocular experience is quantitatively superior in restoring binocular responses in visual cortex neurons. However, this recovery was seen only in freely-sleeping mice; post-experience sleep deprivation prevented functional recovery. Thus, both binocular visual experience and subsequent sleep help to optimally renormalize bV1 responses in a mouse model of amblyopia.
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spelling pubmed-101020752023-04-15 Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia Martinez, Jessy D. Donnelly, Marcus J. Popke, Donald S. Torres, Daniel Wilson, Lydia G. Brancaleone, William P. Sheskey, Sarah Lin, Cheng-mao Clawson, Brittany C. Jiang, Sha Aton, Sara J. Commun Biol Article Studies of primary visual cortex have furthered our understanding of amblyopia, long-lasting visual impairment caused by imbalanced input from the two eyes during childhood, which is commonly treated by patching the dominant eye. However, the relative impacts of monocular vs. binocular visual experiences on recovery from amblyopia are unclear. Moreover, while sleep promotes visual cortex plasticity following loss of input from one eye, its role in recovering binocular visual function is unknown. Using monocular deprivation in juvenile male mice to model amblyopia, we compared recovery of cortical neurons’ visual responses after identical-duration, identical-quality binocular or monocular visual experiences. We demonstrate that binocular experience is quantitatively superior in restoring binocular responses in visual cortex neurons. However, this recovery was seen only in freely-sleeping mice; post-experience sleep deprivation prevented functional recovery. Thus, both binocular visual experience and subsequent sleep help to optimally renormalize bV1 responses in a mouse model of amblyopia. Nature Publishing Group UK 2023-04-13 /pmc/articles/PMC10102075/ /pubmed/37055505 http://dx.doi.org/10.1038/s42003-023-04798-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Martinez, Jessy D.
Donnelly, Marcus J.
Popke, Donald S.
Torres, Daniel
Wilson, Lydia G.
Brancaleone, William P.
Sheskey, Sarah
Lin, Cheng-mao
Clawson, Brittany C.
Jiang, Sha
Aton, Sara J.
Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia
title Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia
title_full Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia
title_fullStr Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia
title_full_unstemmed Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia
title_short Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia
title_sort enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102075/
https://www.ncbi.nlm.nih.gov/pubmed/37055505
http://dx.doi.org/10.1038/s42003-023-04798-y
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