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Prognostic value of metabolic tumor volume of extranodal involvement in diffuse large B cell lymphoma
Extranodal involvement predicts poor outcomes of diffuse large B cell lymphoma (DLBCL), but the impact of the metabolic tumor burden (MTV) of extranodal sites using positron emission tomography has not been clarified. This study aimed to assess the impact of extranodal MTV on overall survival (OS)....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102098/ https://www.ncbi.nlm.nih.gov/pubmed/36951966 http://dx.doi.org/10.1007/s00277-023-05165-x |
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author | Oiwa, Kana Fujita, Kei Lee, Shin Morishita, Tetsuji Tsujikawa, Tetsuya Negoro, Eiju Hara, Takeshi Tsurumi, Hisashi Ueda, Takanori Yamauchi, Takahiro |
author_facet | Oiwa, Kana Fujita, Kei Lee, Shin Morishita, Tetsuji Tsujikawa, Tetsuya Negoro, Eiju Hara, Takeshi Tsurumi, Hisashi Ueda, Takanori Yamauchi, Takahiro |
author_sort | Oiwa, Kana |
collection | PubMed |
description | Extranodal involvement predicts poor outcomes of diffuse large B cell lymphoma (DLBCL), but the impact of the metabolic tumor burden (MTV) of extranodal sites using positron emission tomography has not been clarified. This study aimed to assess the impact of extranodal MTV on overall survival (OS). We retrospectively analyzed 145 newly diagnosed DLBCL patients and verified the prognostic impact of each extranodal and nodal MTV. Multivariate Cox hazards modelling using both extranodal and nodal MTV as covariables identified extranodal MTV as a significant factor for OS (hazard ratio [HR] 1.072, 95% confidence interval [CI] 1.019–1.129, P = 0.008), but not nodal MTV. Multivariate Cox modelling using restricted cubic splines demonstrated that the impact of total MTV depends on the MTV of extranodal sites, not of nodal sites. When both the number and MTV of extranodal involvements were used as covariables, extranodal MTV remained a significant predictor of OS (HR 1.070, 95%CI 1.017–1.127, P = 0.009), but the number of extranodal sites did not. Extranodal MTV potentially had a more significant role on prognosis than nodal MTV. When considering prognostic impacts, the MTV of extranodal involvement is significantly more important than the number. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00277-023-05165-x. |
format | Online Article Text |
id | pubmed-10102098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-101020982023-04-15 Prognostic value of metabolic tumor volume of extranodal involvement in diffuse large B cell lymphoma Oiwa, Kana Fujita, Kei Lee, Shin Morishita, Tetsuji Tsujikawa, Tetsuya Negoro, Eiju Hara, Takeshi Tsurumi, Hisashi Ueda, Takanori Yamauchi, Takahiro Ann Hematol Original Article Extranodal involvement predicts poor outcomes of diffuse large B cell lymphoma (DLBCL), but the impact of the metabolic tumor burden (MTV) of extranodal sites using positron emission tomography has not been clarified. This study aimed to assess the impact of extranodal MTV on overall survival (OS). We retrospectively analyzed 145 newly diagnosed DLBCL patients and verified the prognostic impact of each extranodal and nodal MTV. Multivariate Cox hazards modelling using both extranodal and nodal MTV as covariables identified extranodal MTV as a significant factor for OS (hazard ratio [HR] 1.072, 95% confidence interval [CI] 1.019–1.129, P = 0.008), but not nodal MTV. Multivariate Cox modelling using restricted cubic splines demonstrated that the impact of total MTV depends on the MTV of extranodal sites, not of nodal sites. When both the number and MTV of extranodal involvements were used as covariables, extranodal MTV remained a significant predictor of OS (HR 1.070, 95%CI 1.017–1.127, P = 0.009), but the number of extranodal sites did not. Extranodal MTV potentially had a more significant role on prognosis than nodal MTV. When considering prognostic impacts, the MTV of extranodal involvement is significantly more important than the number. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00277-023-05165-x. Springer Berlin Heidelberg 2023-03-23 2023 /pmc/articles/PMC10102098/ /pubmed/36951966 http://dx.doi.org/10.1007/s00277-023-05165-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Oiwa, Kana Fujita, Kei Lee, Shin Morishita, Tetsuji Tsujikawa, Tetsuya Negoro, Eiju Hara, Takeshi Tsurumi, Hisashi Ueda, Takanori Yamauchi, Takahiro Prognostic value of metabolic tumor volume of extranodal involvement in diffuse large B cell lymphoma |
title | Prognostic value of metabolic tumor volume of extranodal involvement in diffuse large B cell lymphoma |
title_full | Prognostic value of metabolic tumor volume of extranodal involvement in diffuse large B cell lymphoma |
title_fullStr | Prognostic value of metabolic tumor volume of extranodal involvement in diffuse large B cell lymphoma |
title_full_unstemmed | Prognostic value of metabolic tumor volume of extranodal involvement in diffuse large B cell lymphoma |
title_short | Prognostic value of metabolic tumor volume of extranodal involvement in diffuse large B cell lymphoma |
title_sort | prognostic value of metabolic tumor volume of extranodal involvement in diffuse large b cell lymphoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102098/ https://www.ncbi.nlm.nih.gov/pubmed/36951966 http://dx.doi.org/10.1007/s00277-023-05165-x |
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