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A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions

Decision-making requires flexibility to rapidly switch one’s actions in response to sensory stimuli depending on information stored in memory. We identified cortical areas and neural activity patterns underlying this flexibility during virtual navigation, where mice switched navigation toward or awa...

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Autores principales: Kira, Shinichiro, Safaai, Houman, Morcos, Ari S., Panzeri, Stefano, Harvey, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102117/
https://www.ncbi.nlm.nih.gov/pubmed/37055431
http://dx.doi.org/10.1038/s41467-023-37804-2
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author Kira, Shinichiro
Safaai, Houman
Morcos, Ari S.
Panzeri, Stefano
Harvey, Christopher D.
author_facet Kira, Shinichiro
Safaai, Houman
Morcos, Ari S.
Panzeri, Stefano
Harvey, Christopher D.
author_sort Kira, Shinichiro
collection PubMed
description Decision-making requires flexibility to rapidly switch one’s actions in response to sensory stimuli depending on information stored in memory. We identified cortical areas and neural activity patterns underlying this flexibility during virtual navigation, where mice switched navigation toward or away from a visual cue depending on its match to a remembered cue. Optogenetics screening identified V1, posterior parietal cortex (PPC), and retrosplenial cortex (RSC) as necessary for accurate decisions. Calcium imaging revealed neurons that can mediate rapid navigation switches by encoding a mixture of a current and remembered visual cue. These mixed selectivity neurons emerged through task learning and predicted the mouse’s choices by forming efficient population codes before correct, but not incorrect, choices. They were distributed across posterior cortex, even V1, and were densest in RSC and sparsest in PPC. We propose flexibility in navigation decisions arises from neurons that mix visual and memory information within a visual-parietal-retrosplenial network.
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spelling pubmed-101021172023-04-15 A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions Kira, Shinichiro Safaai, Houman Morcos, Ari S. Panzeri, Stefano Harvey, Christopher D. Nat Commun Article Decision-making requires flexibility to rapidly switch one’s actions in response to sensory stimuli depending on information stored in memory. We identified cortical areas and neural activity patterns underlying this flexibility during virtual navigation, where mice switched navigation toward or away from a visual cue depending on its match to a remembered cue. Optogenetics screening identified V1, posterior parietal cortex (PPC), and retrosplenial cortex (RSC) as necessary for accurate decisions. Calcium imaging revealed neurons that can mediate rapid navigation switches by encoding a mixture of a current and remembered visual cue. These mixed selectivity neurons emerged through task learning and predicted the mouse’s choices by forming efficient population codes before correct, but not incorrect, choices. They were distributed across posterior cortex, even V1, and were densest in RSC and sparsest in PPC. We propose flexibility in navigation decisions arises from neurons that mix visual and memory information within a visual-parietal-retrosplenial network. Nature Publishing Group UK 2023-04-14 /pmc/articles/PMC10102117/ /pubmed/37055431 http://dx.doi.org/10.1038/s41467-023-37804-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kira, Shinichiro
Safaai, Houman
Morcos, Ari S.
Panzeri, Stefano
Harvey, Christopher D.
A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions
title A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions
title_full A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions
title_fullStr A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions
title_full_unstemmed A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions
title_short A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions
title_sort distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102117/
https://www.ncbi.nlm.nih.gov/pubmed/37055431
http://dx.doi.org/10.1038/s41467-023-37804-2
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