Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma

Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM. In addition, we identify serine, which is released from MM cells i...

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Detalles Bibliográficos
Autores principales: Kuang, Chunmei, Xia, Meijuan, An, Gang, Liu, CuiCui, Hu, Cong, Zhang, Jingyu, Liu, Zhenhao, Meng, Bin, Su, Pei, Xia, Jiliang, Guo, Jiaojiao, Zhu, Yinghong, Liu, Xing, Wu, Xuan, Shen, Yi, Feng, Xiangling, He, Yanjuan, Li, Jian, Qiu, Lugui, Zhou, Jiaxi, Zhou, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102122/
https://www.ncbi.nlm.nih.gov/pubmed/37055385
http://dx.doi.org/10.1038/s41467-023-37699-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102122/
https://www.ncbi.nlm.nih.gov/pubmed/37055385
http://dx.doi.org/10.1038/s41467-023-37699-z

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