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Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM. In addition, we identify serine, which is released from MM cells i...
Autores principales: | Kuang, Chunmei, Xia, Meijuan, An, Gang, Liu, CuiCui, Hu, Cong, Zhang, Jingyu, Liu, Zhenhao, Meng, Bin, Su, Pei, Xia, Jiliang, Guo, Jiaojiao, Zhu, Yinghong, Liu, Xing, Wu, Xuan, Shen, Yi, Feng, Xiangling, He, Yanjuan, Li, Jian, Qiu, Lugui, Zhou, Jiaxi, Zhou, Wen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102122/ https://www.ncbi.nlm.nih.gov/pubmed/37055385 http://dx.doi.org/10.1038/s41467-023-37699-z |
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