High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production

Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic megakaryocytes (LCM) are critical negative regulators of HSC and critical for platelet formation. Using a mouse knockout model (P...

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Detalles Bibliográficos
Autores principales: Heazlewood, Shen Y., Ahmad, Tanveer, Cao, Benjamin, Cao, Huimin, Domingues, Melanie, Sun, Xuan, Heazlewood, Chad K., Li, Songhui, Williams, Brenda, Fulton, Madeline, White, Jacinta F., Nebl, Tom, Nefzger, Christian M., Polo, Jose M., Kile, Benjamin T., Kraus, Felix, Ryan, Michael T., Sun, Yu B., Choong, Peter F. M., Ellis, Sarah L., Anko, Minna-Liisa, Nilsson, Susan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102126/
https://www.ncbi.nlm.nih.gov/pubmed/37055407
http://dx.doi.org/10.1038/s41467-023-37780-7

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