IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart

Redox signaling and cardiac function are tightly linked. However, it is largely unknown which protein targets are affected by hydrogen peroxide (H(2)O(2)) in cardiomyocytes that underly impaired inotropic effects during oxidative stress. Here, we combine a chemogenetic mouse model (HyPer-DAO mice) a...

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Detalles Bibliográficos
Autores principales: Nanadikar, Maithily S., Vergel Leon, Ana M., Guo, Jia, van Belle, Gijsbert J., Jatho, Aline, Philip, Elvina S., Brandner, Astrid F., Böckmann, Rainer A., Shi, Runzhu, Zieseniss, Anke, Siemssen, Carla M., Dettmer, Katja, Brodesser, Susanne, Schmidtendorf, Marlen, Lee, Jingyun, Wu, Hanzhi, Furdui, Cristina M., Brandenburg, Sören, Burgoyne, Joseph R., Bogeski, Ivan, Riemer, Jan, Chowdhury, Arpita, Rehling, Peter, Bruegmann, Tobias, Belousov, Vsevolod V., Katschinski, Dörthe M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102218/
https://www.ncbi.nlm.nih.gov/pubmed/37055412
http://dx.doi.org/10.1038/s41467-023-37744-x

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