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Diagnostic accuracy of different keratoconus detection indices of pentacam in paediatric eyes
OBJECTIVE: No diagnostic gold standard for keratoconus in children and adolescents exists. Our objective was investigating the diagnostic accuracy of various indices for keratoconus (KC) detection in paediatric eyes. METHODS: All retrievable data of significance from 432 normal right paediatric eyes...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102329/ https://www.ncbi.nlm.nih.gov/pubmed/35505110 http://dx.doi.org/10.1038/s41433-022-02070-x |
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author | Hashem, Ahmed Osama Aziz, Bassem Fayez Wahba, Sherine Shafik Roshdy, Maged Maher Elawamry, Amr Ismail |
author_facet | Hashem, Ahmed Osama Aziz, Bassem Fayez Wahba, Sherine Shafik Roshdy, Maged Maher Elawamry, Amr Ismail |
author_sort | Hashem, Ahmed Osama |
collection | PubMed |
description | OBJECTIVE: No diagnostic gold standard for keratoconus in children and adolescents exists. Our objective was investigating the diagnostic accuracy of various indices for keratoconus (KC) detection in paediatric eyes. METHODS: All retrievable data of significance from 432 normal right paediatric eyes and 48 eyes of paediatric KC and forme fruste KC (FFKC), imaged by use of a rotating Scheimpflug camera (Oculyzer II, Pentacam HR) between December 2013 and October 2018 at Watany Eye Hospitals, Cairo, Egypt, including Scheimpflug images data, were collected. The area under the receiver operating characteristic curve (AUROC) was calculated for different indices in this retrospective descriptive study. RESULTS: All 36 tested indices showed discriminative power differentiating KC and FFKC from normal corneas (AUROC P-value <0.05), except AC volume, AC angle, and horizontal decentrations of the steepest and thinnest points. The 32 indices showed variable degrees of diagnostic accuracy. The highest AUROC was that of the corneal assessment index from the relational thickness and other OCULUS values (CAIRO 8). Only 8 indices showed non-inferiority to it, namely, Ambrosio’s relational thickness maximum (ART max) and avg, the pachymetric progression index maximum (PPI max) and avg, the back elevation from the best-fit toric ellipsoid (BE BFTE), the KC index (KI), the topographic KC indices (TKC), and the index of height decentration (IHD) (P > 0.05). CONCLUSIONS: The 8 most useful rotating Scheimpflug imaging indices for KC detection in paediatric eyes are CAIRO 8 followed by ART max and avg, PPI max and avg, BE BFTE, KI, TKC, and IHD. |
format | Online Article Text |
id | pubmed-10102329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101023292023-04-15 Diagnostic accuracy of different keratoconus detection indices of pentacam in paediatric eyes Hashem, Ahmed Osama Aziz, Bassem Fayez Wahba, Sherine Shafik Roshdy, Maged Maher Elawamry, Amr Ismail Eye (Lond) Article OBJECTIVE: No diagnostic gold standard for keratoconus in children and adolescents exists. Our objective was investigating the diagnostic accuracy of various indices for keratoconus (KC) detection in paediatric eyes. METHODS: All retrievable data of significance from 432 normal right paediatric eyes and 48 eyes of paediatric KC and forme fruste KC (FFKC), imaged by use of a rotating Scheimpflug camera (Oculyzer II, Pentacam HR) between December 2013 and October 2018 at Watany Eye Hospitals, Cairo, Egypt, including Scheimpflug images data, were collected. The area under the receiver operating characteristic curve (AUROC) was calculated for different indices in this retrospective descriptive study. RESULTS: All 36 tested indices showed discriminative power differentiating KC and FFKC from normal corneas (AUROC P-value <0.05), except AC volume, AC angle, and horizontal decentrations of the steepest and thinnest points. The 32 indices showed variable degrees of diagnostic accuracy. The highest AUROC was that of the corneal assessment index from the relational thickness and other OCULUS values (CAIRO 8). Only 8 indices showed non-inferiority to it, namely, Ambrosio’s relational thickness maximum (ART max) and avg, the pachymetric progression index maximum (PPI max) and avg, the back elevation from the best-fit toric ellipsoid (BE BFTE), the KC index (KI), the topographic KC indices (TKC), and the index of height decentration (IHD) (P > 0.05). CONCLUSIONS: The 8 most useful rotating Scheimpflug imaging indices for KC detection in paediatric eyes are CAIRO 8 followed by ART max and avg, PPI max and avg, BE BFTE, KI, TKC, and IHD. Nature Publishing Group UK 2022-05-03 2023-04 /pmc/articles/PMC10102329/ /pubmed/35505110 http://dx.doi.org/10.1038/s41433-022-02070-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hashem, Ahmed Osama Aziz, Bassem Fayez Wahba, Sherine Shafik Roshdy, Maged Maher Elawamry, Amr Ismail Diagnostic accuracy of different keratoconus detection indices of pentacam in paediatric eyes |
title | Diagnostic accuracy of different keratoconus detection indices of pentacam in paediatric eyes |
title_full | Diagnostic accuracy of different keratoconus detection indices of pentacam in paediatric eyes |
title_fullStr | Diagnostic accuracy of different keratoconus detection indices of pentacam in paediatric eyes |
title_full_unstemmed | Diagnostic accuracy of different keratoconus detection indices of pentacam in paediatric eyes |
title_short | Diagnostic accuracy of different keratoconus detection indices of pentacam in paediatric eyes |
title_sort | diagnostic accuracy of different keratoconus detection indices of pentacam in paediatric eyes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102329/ https://www.ncbi.nlm.nih.gov/pubmed/35505110 http://dx.doi.org/10.1038/s41433-022-02070-x |
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