Cargando…
Mercury intoxication and ophthalmic involvement: An update review
Human intoxication after mercury exposure is a rare condition that can cause severe damage to the central nervous, respiratory, cardiovascular, renal, gastrointestinal, skin, and visual systems and represents a major public health concern. Ophthalmic involvement includes impaired function of the ext...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102333/ https://www.ncbi.nlm.nih.gov/pubmed/37063600 http://dx.doi.org/10.3389/ftox.2023.1148357 |
_version_ | 1785025672293384192 |
---|---|
author | de los Santos, Cristian Pastor, J. Carlos Calonge, Margarita |
author_facet | de los Santos, Cristian Pastor, J. Carlos Calonge, Margarita |
author_sort | de los Santos, Cristian |
collection | PubMed |
description | Human intoxication after mercury exposure is a rare condition that can cause severe damage to the central nervous, respiratory, cardiovascular, renal, gastrointestinal, skin, and visual systems and represents a major public health concern. Ophthalmic involvement includes impaired function of the extraocular muscles and the eyelids, as well as structural changes in the ocular surface, lens, retina, and optic nerve causing a potential irreversible damage to the visual system. Although, there are many pathways for poisoning depending on the mercury form, it has been suggested that tissue distribution does not differ in experimental animals when administered as mercury vapor, organic mercury, or inorganic mercury. Additionally, visual function alterations regarding central visual acuity, color discrimination, contrast sensitivity, visual field and electroretinogram responses have also been described widely. Nevertheless, there is still controversy about whether visual manifestations occur secondary to brain damage or as a direct affectation, and which ocular structure is primarily affected. Despite the use of some imaging techniques such as in vivo confocal microscopy of the cornea, optical coherence tomography (OCT) of the retina and optic nerve, and functional tests such as electroretinography has helped to solve in part this debate, further studies incorporating other imaging modalities such as autofluorescence, OCT angiography or adaptive optics retinal imaging are needed. This review aims to summarize the published structural and functional alterations found in the visual system of patients suffering from mercury intoxication. |
format | Online Article Text |
id | pubmed-10102333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101023332023-04-15 Mercury intoxication and ophthalmic involvement: An update review de los Santos, Cristian Pastor, J. Carlos Calonge, Margarita Front Toxicol Toxicology Human intoxication after mercury exposure is a rare condition that can cause severe damage to the central nervous, respiratory, cardiovascular, renal, gastrointestinal, skin, and visual systems and represents a major public health concern. Ophthalmic involvement includes impaired function of the extraocular muscles and the eyelids, as well as structural changes in the ocular surface, lens, retina, and optic nerve causing a potential irreversible damage to the visual system. Although, there are many pathways for poisoning depending on the mercury form, it has been suggested that tissue distribution does not differ in experimental animals when administered as mercury vapor, organic mercury, or inorganic mercury. Additionally, visual function alterations regarding central visual acuity, color discrimination, contrast sensitivity, visual field and electroretinogram responses have also been described widely. Nevertheless, there is still controversy about whether visual manifestations occur secondary to brain damage or as a direct affectation, and which ocular structure is primarily affected. Despite the use of some imaging techniques such as in vivo confocal microscopy of the cornea, optical coherence tomography (OCT) of the retina and optic nerve, and functional tests such as electroretinography has helped to solve in part this debate, further studies incorporating other imaging modalities such as autofluorescence, OCT angiography or adaptive optics retinal imaging are needed. This review aims to summarize the published structural and functional alterations found in the visual system of patients suffering from mercury intoxication. Frontiers Media S.A. 2023-03-31 /pmc/articles/PMC10102333/ /pubmed/37063600 http://dx.doi.org/10.3389/ftox.2023.1148357 Text en Copyright © 2023 de los Santos, Pastor and Calonge. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Toxicology de los Santos, Cristian Pastor, J. Carlos Calonge, Margarita Mercury intoxication and ophthalmic involvement: An update review |
title | Mercury intoxication and ophthalmic involvement: An update review |
title_full | Mercury intoxication and ophthalmic involvement: An update review |
title_fullStr | Mercury intoxication and ophthalmic involvement: An update review |
title_full_unstemmed | Mercury intoxication and ophthalmic involvement: An update review |
title_short | Mercury intoxication and ophthalmic involvement: An update review |
title_sort | mercury intoxication and ophthalmic involvement: an update review |
topic | Toxicology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102333/ https://www.ncbi.nlm.nih.gov/pubmed/37063600 http://dx.doi.org/10.3389/ftox.2023.1148357 |
work_keys_str_mv | AT delossantoscristian mercuryintoxicationandophthalmicinvolvementanupdatereview AT pastorjcarlos mercuryintoxicationandophthalmicinvolvementanupdatereview AT calongemargarita mercuryintoxicationandophthalmicinvolvementanupdatereview |