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Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

Natural products derived from herbal medicine are a fruitful source of lead compounds because of their structural diversity and potent bioactivities. However, despite the success of active compounds derived from herbal medicine in drug discovery, some approaches cannot effectively elucidate the over...

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Autores principales: Guo, Sifan, Qiu, Shi, Cai, Ying, Wang, Zhibo, Yang, Qiang, Tang, Songqi, Xie, Yiqiang, Zhang, Aihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102349/
https://www.ncbi.nlm.nih.gov/pubmed/37065828
http://dx.doi.org/10.3389/fchem.2023.1142287
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author Guo, Sifan
Qiu, Shi
Cai, Ying
Wang, Zhibo
Yang, Qiang
Tang, Songqi
Xie, Yiqiang
Zhang, Aihua
author_facet Guo, Sifan
Qiu, Shi
Cai, Ying
Wang, Zhibo
Yang, Qiang
Tang, Songqi
Xie, Yiqiang
Zhang, Aihua
author_sort Guo, Sifan
collection PubMed
description Natural products derived from herbal medicine are a fruitful source of lead compounds because of their structural diversity and potent bioactivities. However, despite the success of active compounds derived from herbal medicine in drug discovery, some approaches cannot effectively elucidate the overall effect and action mechanism due to their multi-component complexity. Fortunately, mass spectrometry-based metabolomics has been recognized as an effective strategy for revealing the effect and discovering active components, detailed molecular mechanisms, and multiple targets of natural products. Rapid identification of lead compounds and isolation of active components from natural products would facilitate new drug development. In this context, mass spectrometry-based metabolomics has established an integrated pharmacology framework for the discovery of bioactivity-correlated constituents, target identification, and the action mechanism of herbal medicine and natural products. High-throughput functional metabolomics techniques could be used to identify natural product structure, biological activity, efficacy mechanisms, and their mode of action on biological processes, assisting bioactive lead discovery, quality control, and accelerating discovery of novel drugs. These techniques are increasingly being developed in the era of big data and use scientific language to clarify the detailed action mechanism of herbal medicine. In this paper, the analytical characteristics and application fields of several commonly used mass spectrometers are introduced, and the application of mass spectrometry in the metabolomics of traditional Chinese medicines in recent years and its active components as well as mechanism of action are also discussed.
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spelling pubmed-101023492023-04-15 Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine Guo, Sifan Qiu, Shi Cai, Ying Wang, Zhibo Yang, Qiang Tang, Songqi Xie, Yiqiang Zhang, Aihua Front Chem Chemistry Natural products derived from herbal medicine are a fruitful source of lead compounds because of their structural diversity and potent bioactivities. However, despite the success of active compounds derived from herbal medicine in drug discovery, some approaches cannot effectively elucidate the overall effect and action mechanism due to their multi-component complexity. Fortunately, mass spectrometry-based metabolomics has been recognized as an effective strategy for revealing the effect and discovering active components, detailed molecular mechanisms, and multiple targets of natural products. Rapid identification of lead compounds and isolation of active components from natural products would facilitate new drug development. In this context, mass spectrometry-based metabolomics has established an integrated pharmacology framework for the discovery of bioactivity-correlated constituents, target identification, and the action mechanism of herbal medicine and natural products. High-throughput functional metabolomics techniques could be used to identify natural product structure, biological activity, efficacy mechanisms, and their mode of action on biological processes, assisting bioactive lead discovery, quality control, and accelerating discovery of novel drugs. These techniques are increasingly being developed in the era of big data and use scientific language to clarify the detailed action mechanism of herbal medicine. In this paper, the analytical characteristics and application fields of several commonly used mass spectrometers are introduced, and the application of mass spectrometry in the metabolomics of traditional Chinese medicines in recent years and its active components as well as mechanism of action are also discussed. Frontiers Media S.A. 2023-03-31 /pmc/articles/PMC10102349/ /pubmed/37065828 http://dx.doi.org/10.3389/fchem.2023.1142287 Text en Copyright © 2023 Guo, Qiu, Cai, Wang, Yang, Tang, Xie and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Guo, Sifan
Qiu, Shi
Cai, Ying
Wang, Zhibo
Yang, Qiang
Tang, Songqi
Xie, Yiqiang
Zhang, Aihua
Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine
title Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine
title_full Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine
title_fullStr Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine
title_full_unstemmed Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine
title_short Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine
title_sort mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102349/
https://www.ncbi.nlm.nih.gov/pubmed/37065828
http://dx.doi.org/10.3389/fchem.2023.1142287
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