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Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child
Primary extraskeletal Ewing sarcoma (EES) is a rare small round cell malignancy that accounts for less than 1% of all sarcomas. It is found most commonly in the trunk and lower limbs and very rarely in the pleura and can be easily misdiagnosed in clinical practice. This study presents the case of an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102462/ https://www.ncbi.nlm.nih.gov/pubmed/37064103 http://dx.doi.org/10.3389/fonc.2023.1137586 |
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author | Wu, Yang Xie, Chao-Bang Huang, Qiong Zhao, Kai-Fei |
author_facet | Wu, Yang Xie, Chao-Bang Huang, Qiong Zhao, Kai-Fei |
author_sort | Wu, Yang |
collection | PubMed |
description | Primary extraskeletal Ewing sarcoma (EES) is a rare small round cell malignancy that accounts for less than 1% of all sarcomas. It is found most commonly in the trunk and lower limbs and very rarely in the pleura and can be easily misdiagnosed in clinical practice. This study presents the case of an 11-year-old boy who presented to our hospital with no apparent cause of left shoulder pain for 6 months. On physical examination, tenderness was noted in the left chest wall and shoulder joint, which had a limited range of motion. Computed tomography (CT) and magnetic resonance imaging (MRI) of the chest revealed an irregular soft tissue mass in the upper left thorax, with a wide base attached to the adjacent pleura and bone destruction of the adjacent left first rib. The patient’s bone scan showed a dense focus of increased radiotracer accumulation in the left first rib. A subsequent CT-guided aspiration biopsy of the left pleural mass with histomorphology and immunohistochemical phenotyping led to a diagnosis of extraskeletal Ewing sarcoma. To inhibit tumor growth, alternating systemic chemotherapy cycles of vincristine, doxorubicin, and cyclophosphamide (VDC) and isocyclophosphamide and etoposide (IE) were administered at 3-week intervals. After completing three VDC and two IE cycles, the child’s condition was well and the pain in the left shoulder joint was relieved. However, a repeat MRI of the chest showed that the mass did not shrink. |
format | Online Article Text |
id | pubmed-10102462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101024622023-04-15 Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child Wu, Yang Xie, Chao-Bang Huang, Qiong Zhao, Kai-Fei Front Oncol Oncology Primary extraskeletal Ewing sarcoma (EES) is a rare small round cell malignancy that accounts for less than 1% of all sarcomas. It is found most commonly in the trunk and lower limbs and very rarely in the pleura and can be easily misdiagnosed in clinical practice. This study presents the case of an 11-year-old boy who presented to our hospital with no apparent cause of left shoulder pain for 6 months. On physical examination, tenderness was noted in the left chest wall and shoulder joint, which had a limited range of motion. Computed tomography (CT) and magnetic resonance imaging (MRI) of the chest revealed an irregular soft tissue mass in the upper left thorax, with a wide base attached to the adjacent pleura and bone destruction of the adjacent left first rib. The patient’s bone scan showed a dense focus of increased radiotracer accumulation in the left first rib. A subsequent CT-guided aspiration biopsy of the left pleural mass with histomorphology and immunohistochemical phenotyping led to a diagnosis of extraskeletal Ewing sarcoma. To inhibit tumor growth, alternating systemic chemotherapy cycles of vincristine, doxorubicin, and cyclophosphamide (VDC) and isocyclophosphamide and etoposide (IE) were administered at 3-week intervals. After completing three VDC and two IE cycles, the child’s condition was well and the pain in the left shoulder joint was relieved. However, a repeat MRI of the chest showed that the mass did not shrink. Frontiers Media S.A. 2023-03-31 /pmc/articles/PMC10102462/ /pubmed/37064103 http://dx.doi.org/10.3389/fonc.2023.1137586 Text en Copyright © 2023 Wu, Xie, Huang and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wu, Yang Xie, Chao-Bang Huang, Qiong Zhao, Kai-Fei Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child |
title | Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child |
title_full | Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child |
title_fullStr | Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child |
title_full_unstemmed | Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child |
title_short | Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child |
title_sort | case report: primary pleural giant extraskeletal ewing sarcoma in a child |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102462/ https://www.ncbi.nlm.nih.gov/pubmed/37064103 http://dx.doi.org/10.3389/fonc.2023.1137586 |
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