A close look at current γδ T-cell immunotherapy

Owing to their antitumor and major histocompatibility complex (MHC)-independent capacities, γδ T cells have gained popularity in adoptive T-cell immunotherapy in recent years. However, many unknowns still exist regarding γδ T cells, and few clinical data have been collected. Therefore, this review a...

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Detalles Bibliográficos
Autores principales: Ma, Ling, Feng, Yanmin, Zhou, Zishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102511/
https://www.ncbi.nlm.nih.gov/pubmed/37063836
http://dx.doi.org/10.3389/fimmu.2023.1140623
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author Ma, Ling
Feng, Yanmin
Zhou, Zishan
author_facet Ma, Ling
Feng, Yanmin
Zhou, Zishan
author_sort Ma, Ling
collection PubMed
description Owing to their antitumor and major histocompatibility complex (MHC)-independent capacities, γδ T cells have gained popularity in adoptive T-cell immunotherapy in recent years. However, many unknowns still exist regarding γδ T cells, and few clinical data have been collected. Therefore, this review aims to describe all the main features of the applications of γδ T cells and provide a systematic view of current γδ T-cell immunotherapy. Specifically, this review will focus on how γδ T cells performed in treating cancers in clinics, on the γδ T-cell clinical trials that have been conducted to date, and the role of γδ T cells in the pharmaceutical industry.
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spelling pubmed-101025112023-04-15 A close look at current γδ T-cell immunotherapy Ma, Ling Feng, Yanmin Zhou, Zishan Front Immunol Immunology Owing to their antitumor and major histocompatibility complex (MHC)-independent capacities, γδ T cells have gained popularity in adoptive T-cell immunotherapy in recent years. However, many unknowns still exist regarding γδ T cells, and few clinical data have been collected. Therefore, this review aims to describe all the main features of the applications of γδ T cells and provide a systematic view of current γδ T-cell immunotherapy. Specifically, this review will focus on how γδ T cells performed in treating cancers in clinics, on the γδ T-cell clinical trials that have been conducted to date, and the role of γδ T cells in the pharmaceutical industry. Frontiers Media S.A. 2023-03-31 /pmc/articles/PMC10102511/ /pubmed/37063836 http://dx.doi.org/10.3389/fimmu.2023.1140623 Text en Copyright © 2023 Ma, Feng and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ma, Ling
Feng, Yanmin
Zhou, Zishan
A close look at current γδ T-cell immunotherapy
title A close look at current γδ T-cell immunotherapy
title_full A close look at current γδ T-cell immunotherapy
title_fullStr A close look at current γδ T-cell immunotherapy
title_full_unstemmed A close look at current γδ T-cell immunotherapy
title_short A close look at current γδ T-cell immunotherapy
title_sort close look at current γδ t-cell immunotherapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102511/
https://www.ncbi.nlm.nih.gov/pubmed/37063836
http://dx.doi.org/10.3389/fimmu.2023.1140623
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