Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution

BACKGROUND: Kidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were developed based on their effect on T-cell activation rather than the underlying mechanisms driving alloimmune responses. Thus, u...

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Detalles Bibliográficos
Autores principales: Halawi, Ahmad, El Kurdi, Abdullah B., Vernon, Katherine A., Solhjou, Zhabiz, Choi, John Y., Saad, Anis J., Younis, Nour K., Elfekih, Rania, Mohammed, Mostafa Tawfeek, Deban, Christa A., Weins, Astrid, Abdi, Reza, Riella, Leonardo V., De Serres, Sasha A., Cravedi, Paolo, Greka, Anna, Khoueiry, Pierre, Azzi, Jamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102512/
https://www.ncbi.nlm.nih.gov/pubmed/37063857
http://dx.doi.org/10.3389/fimmu.2023.1139358

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