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Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis is the main factor causing ventricular wall stiffness and heart failure in DCM. Early control of myocardial fibrosis in D...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102655/ https://www.ncbi.nlm.nih.gov/pubmed/37065745 http://dx.doi.org/10.3389/fendo.2023.1162754 |
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author | Cheng, Yanan Wang, Yan Yin, Ruili Xu, Yongsong Zhang, Lijie Zhang, Yuanyuan Yang, Longyan Zhao, Dong |
author_facet | Cheng, Yanan Wang, Yan Yin, Ruili Xu, Yongsong Zhang, Lijie Zhang, Yuanyuan Yang, Longyan Zhao, Dong |
author_sort | Cheng, Yanan |
collection | PubMed |
description | Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis is the main factor causing ventricular wall stiffness and heart failure in DCM. Early control of myocardial fibrosis in DCM is of great significance to prevent or postpone the progression of DCM to heart failure. A growing body of evidence suggests that cardiomyocytes, immunocytes, and endothelial cells involve fibrogenic actions, however, cardiac fibroblasts, the main participants in collagen production, are situated in the most central position in cardiac fibrosis. In this review, we systematically elaborate the source and physiological role of myocardial fibroblasts in the context of DCM, and we also discuss the potential action and mechanism of cardiac fibroblasts in promoting fibrosis, so as to provide guidance for formulating strategies for prevention and treatment of cardiac fibrosis in DCM. |
format | Online Article Text |
id | pubmed-10102655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101026552023-04-15 Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy Cheng, Yanan Wang, Yan Yin, Ruili Xu, Yongsong Zhang, Lijie Zhang, Yuanyuan Yang, Longyan Zhao, Dong Front Endocrinol (Lausanne) Endocrinology Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis is the main factor causing ventricular wall stiffness and heart failure in DCM. Early control of myocardial fibrosis in DCM is of great significance to prevent or postpone the progression of DCM to heart failure. A growing body of evidence suggests that cardiomyocytes, immunocytes, and endothelial cells involve fibrogenic actions, however, cardiac fibroblasts, the main participants in collagen production, are situated in the most central position in cardiac fibrosis. In this review, we systematically elaborate the source and physiological role of myocardial fibroblasts in the context of DCM, and we also discuss the potential action and mechanism of cardiac fibroblasts in promoting fibrosis, so as to provide guidance for formulating strategies for prevention and treatment of cardiac fibrosis in DCM. Frontiers Media S.A. 2023-03-31 /pmc/articles/PMC10102655/ /pubmed/37065745 http://dx.doi.org/10.3389/fendo.2023.1162754 Text en Copyright © 2023 Cheng, Wang, Yin, Xu, Zhang, Zhang, Yang and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Cheng, Yanan Wang, Yan Yin, Ruili Xu, Yongsong Zhang, Lijie Zhang, Yuanyuan Yang, Longyan Zhao, Dong Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
title | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
title_full | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
title_fullStr | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
title_full_unstemmed | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
title_short | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
title_sort | central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102655/ https://www.ncbi.nlm.nih.gov/pubmed/37065745 http://dx.doi.org/10.3389/fendo.2023.1162754 |
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