Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19: a multicentre, randomised, double-blind, non-inferiority phase IIb trial

BACKGROUND: A SARS-CoV-2 protein-based heterodimer vaccine, PHH-1V, has been shown to be safe and well-tolerated in healthy young adults in a first-in-human, Phase I/IIa study dose-escalation trial. Here, we report the interim results of the Phase IIb HH-2, where the immunogenicity and safety of a h...

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Detalles Bibliográficos
Autores principales: Corominas, Júlia, Garriga, Carme, Prenafeta, Antoni, Moros, Alexandra, Cañete, Manuel, Barreiro, Antonio, González-González, Luis, Madrenas, Laia, Güell, Irina, Clotet, Bonaventura, Izquierdo-Useros, Nuria, Raïch-Regué, Dàlia, Gallemí, Marçal, Blanco, Julià, Pradenas, Edwards, Trinité, Benjamin, Prado, Julia G., Blanch-Lombarte, Oscar, Pérez-Caballero, Raúl, Plana, Montserrat, Esteban, Ignasi, Pastor-Quiñones, Carmen, Núñez-Costa, Xavier, Taleb, Rachel Abu, McSkimming, Paula, Soriano, Alex, Nava, Jocelyn, Anagua, Jesse Omar, Ramos, Rafel, Lluch, Ruth Martí, Comes, Aida Corpes, Romero, Susana Otero, Gomez, Xavier Martinez, Sans-Pola, Carla, Moltó, José, Benet, Susana, Bailón, Lucía, Arribas, Jose R., Borobia, Alberto M., Parada, Javier Queiruga, Navarro-Pérez, Jorge, Forner Giner, Maria José, Lucas, Rafael Ortí, Jiménez, María del Mar Vázquez, Compán, Salvador Oña, Alvarez-Mon, Melchor, Troncoso, Daniel, Arana-Arri, Eunate, Meijide, Susana, Imaz-Ayo, Natale, García, Patricia Muñoz, de la Villa Martínez, Sofía, Fernández, Sara Rodríguez, Prat, Teresa, Torroella, Èlia, Ferrer, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102678/
https://www.ncbi.nlm.nih.gov/pubmed/37131861
http://dx.doi.org/10.1016/j.lanepe.2023.100613

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