Cargando…

Comparison of single-postlabeling delay and seven-delay three-dimensional pseudo-continuous arterial spin labeling in the assessment of intracranial atherosclerotic disease

BACKGROUND: The assessment of cerebral blood flow (CBF) is crucial in the evaluation of intracranial atherosclerotic disease. This study was performed to compare single postlabeling delay (PLD) 3-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) and 7-delay 3D-pCASL magnetic resonance...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Hongwei, Ouyang, Yiping, Feng, Yibo, Sun, Shilong, Zhang, Linwei, Liu, Zunjing, Tian, Hong, Xie, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102769/
https://www.ncbi.nlm.nih.gov/pubmed/37064395
http://dx.doi.org/10.21037/qims-22-969
_version_ 1785025758137155584
author Yu, Hongwei
Ouyang, Yiping
Feng, Yibo
Sun, Shilong
Zhang, Linwei
Liu, Zunjing
Tian, Hong
Xie, Sheng
author_facet Yu, Hongwei
Ouyang, Yiping
Feng, Yibo
Sun, Shilong
Zhang, Linwei
Liu, Zunjing
Tian, Hong
Xie, Sheng
author_sort Yu, Hongwei
collection PubMed
description BACKGROUND: The assessment of cerebral blood flow (CBF) is crucial in the evaluation of intracranial atherosclerotic disease. This study was performed to compare single postlabeling delay (PLD) 3-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) and 7-delay 3D-pCASL magnetic resonance imaging in patients with intracranial atherosclerotic stenosis. METHODS: A total of 26 patients with moderate to severe atherosclerotic stenosis or occlusion of an intracranial artery were prospectively enrolled in the study. Perfusion parameters were obtained in various regions of interest (ROIs), namely CBF for single PLDs of 1,525 ms (CBF(1525 ms)), 2,025 ms (CBF(2025 ms)), and 2,525 ms (CBF(2525 ms)) with 3D-pCASL, as well as arterial transit time (ATT) and transit-corrected CBF (CBF(transit-corrected)) for 7-delay 3D-pCASL. The consistency of the perfusion parameters between single-PLD 3D-pCASL and 7-delay 3D-pCASL was investigated, and the relationship between vascular stenosis and perfusion parameters was explored. RESULTS: Bland-Altman plots compared the CBF values derived from single-PLD 3D-pCASL to those from CBF(transit-corrected). ATT significantly correlated with the difference between CBF(transit-corrected) and CBF(1525 ms), CBF(2025 ms, and )CBF(2525 ms), respectively (P<0.05). Binary logistic regression analysis revealed that the CBF(transit-corrected) and ATT correlated with the presence of moderate or more severe stenotic vascular territories (P<0.05). CONCLUSIONS: The single-PLD 3D-pCASL and the 7-delay 3D-pCASL showed inconsistencies in the assessment of CBF, and the perfusion parameters generated under the standard single-PLD 3D-pCASL were more affected by ATT. Moreover, CBF(transit-corrected )and ATT were consistent with stenotic vascular territories, which is useful in the evaluation of intracranial atherosclerotic disease.
format Online
Article
Text
id pubmed-10102769
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-101027692023-04-15 Comparison of single-postlabeling delay and seven-delay three-dimensional pseudo-continuous arterial spin labeling in the assessment of intracranial atherosclerotic disease Yu, Hongwei Ouyang, Yiping Feng, Yibo Sun, Shilong Zhang, Linwei Liu, Zunjing Tian, Hong Xie, Sheng Quant Imaging Med Surg Original Article BACKGROUND: The assessment of cerebral blood flow (CBF) is crucial in the evaluation of intracranial atherosclerotic disease. This study was performed to compare single postlabeling delay (PLD) 3-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) and 7-delay 3D-pCASL magnetic resonance imaging in patients with intracranial atherosclerotic stenosis. METHODS: A total of 26 patients with moderate to severe atherosclerotic stenosis or occlusion of an intracranial artery were prospectively enrolled in the study. Perfusion parameters were obtained in various regions of interest (ROIs), namely CBF for single PLDs of 1,525 ms (CBF(1525 ms)), 2,025 ms (CBF(2025 ms)), and 2,525 ms (CBF(2525 ms)) with 3D-pCASL, as well as arterial transit time (ATT) and transit-corrected CBF (CBF(transit-corrected)) for 7-delay 3D-pCASL. The consistency of the perfusion parameters between single-PLD 3D-pCASL and 7-delay 3D-pCASL was investigated, and the relationship between vascular stenosis and perfusion parameters was explored. RESULTS: Bland-Altman plots compared the CBF values derived from single-PLD 3D-pCASL to those from CBF(transit-corrected). ATT significantly correlated with the difference between CBF(transit-corrected) and CBF(1525 ms), CBF(2025 ms, and )CBF(2525 ms), respectively (P<0.05). Binary logistic regression analysis revealed that the CBF(transit-corrected) and ATT correlated with the presence of moderate or more severe stenotic vascular territories (P<0.05). CONCLUSIONS: The single-PLD 3D-pCASL and the 7-delay 3D-pCASL showed inconsistencies in the assessment of CBF, and the perfusion parameters generated under the standard single-PLD 3D-pCASL were more affected by ATT. Moreover, CBF(transit-corrected )and ATT were consistent with stenotic vascular territories, which is useful in the evaluation of intracranial atherosclerotic disease. AME Publishing Company 2023-02-09 2023-04-01 /pmc/articles/PMC10102769/ /pubmed/37064395 http://dx.doi.org/10.21037/qims-22-969 Text en 2023 Quantitative Imaging in Medicine and Surgery. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Yu, Hongwei
Ouyang, Yiping
Feng, Yibo
Sun, Shilong
Zhang, Linwei
Liu, Zunjing
Tian, Hong
Xie, Sheng
Comparison of single-postlabeling delay and seven-delay three-dimensional pseudo-continuous arterial spin labeling in the assessment of intracranial atherosclerotic disease
title Comparison of single-postlabeling delay and seven-delay three-dimensional pseudo-continuous arterial spin labeling in the assessment of intracranial atherosclerotic disease
title_full Comparison of single-postlabeling delay and seven-delay three-dimensional pseudo-continuous arterial spin labeling in the assessment of intracranial atherosclerotic disease
title_fullStr Comparison of single-postlabeling delay and seven-delay three-dimensional pseudo-continuous arterial spin labeling in the assessment of intracranial atherosclerotic disease
title_full_unstemmed Comparison of single-postlabeling delay and seven-delay three-dimensional pseudo-continuous arterial spin labeling in the assessment of intracranial atherosclerotic disease
title_short Comparison of single-postlabeling delay and seven-delay three-dimensional pseudo-continuous arterial spin labeling in the assessment of intracranial atherosclerotic disease
title_sort comparison of single-postlabeling delay and seven-delay three-dimensional pseudo-continuous arterial spin labeling in the assessment of intracranial atherosclerotic disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102769/
https://www.ncbi.nlm.nih.gov/pubmed/37064395
http://dx.doi.org/10.21037/qims-22-969
work_keys_str_mv AT yuhongwei comparisonofsinglepostlabelingdelayandsevendelaythreedimensionalpseudocontinuousarterialspinlabelingintheassessmentofintracranialatheroscleroticdisease
AT ouyangyiping comparisonofsinglepostlabelingdelayandsevendelaythreedimensionalpseudocontinuousarterialspinlabelingintheassessmentofintracranialatheroscleroticdisease
AT fengyibo comparisonofsinglepostlabelingdelayandsevendelaythreedimensionalpseudocontinuousarterialspinlabelingintheassessmentofintracranialatheroscleroticdisease
AT sunshilong comparisonofsinglepostlabelingdelayandsevendelaythreedimensionalpseudocontinuousarterialspinlabelingintheassessmentofintracranialatheroscleroticdisease
AT zhanglinwei comparisonofsinglepostlabelingdelayandsevendelaythreedimensionalpseudocontinuousarterialspinlabelingintheassessmentofintracranialatheroscleroticdisease
AT liuzunjing comparisonofsinglepostlabelingdelayandsevendelaythreedimensionalpseudocontinuousarterialspinlabelingintheassessmentofintracranialatheroscleroticdisease
AT tianhong comparisonofsinglepostlabelingdelayandsevendelaythreedimensionalpseudocontinuousarterialspinlabelingintheassessmentofintracranialatheroscleroticdisease
AT xiesheng comparisonofsinglepostlabelingdelayandsevendelaythreedimensionalpseudocontinuousarterialspinlabelingintheassessmentofintracranialatheroscleroticdisease