Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

PURPOSE: DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but is frequently overexpressed in cancer cells and, therefore, represents an ideal target for tumor-specific ra...

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Detalles Bibliográficos
Autores principales: Rodriguez-Berriguete, Gonzalo, Ranzani, Marco, Prevo, Remko, Puliyadi, Rathi, Machado, Nicole, Bolland, Hannah R., Millar, Val, Ebner, Daniel, Boursier, Marie, Cerutti, Aurora, Cicconi, Alessandro, Galbiati, Alessandro, Grande, Diego, Grinkevich, Vera, Majithiya, Jayesh B., Piscitello, Desiree, Rajendra, Eeson, Stockley, Martin L., Boulton, Simon J., Hammond, Ester M., Heald, Robert A., Smith, Graeme C.M., Robinson, Helen M.R., Higgins, Geoff S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102842/
https://www.ncbi.nlm.nih.gov/pubmed/36689546
http://dx.doi.org/10.1158/1078-0432.CCR-22-2977

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