MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

PURPOSE: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases are associated with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome. Overexpression of TYK2 occurs in the majority of...

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Detalles Bibliográficos
Autores principales: Borcherding, Dana C., Amin, Neha V., He, Kevin, Zhang, Xiaochun, Lyu, Yang, Dehner, Carina, Bhatia, Himanshi, Gothra, Angad, Daud, Layla, Ruminski, Peter, Pratilas, Christine A., Pollard, Kai, Sundby, Taylor, Widemann, Brigitte C., Hirbe, Angela C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
https://www.ncbi.nlm.nih.gov/pubmed/36799629
http://dx.doi.org/10.1158/1078-0432.CCR-22-3722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
https://www.ncbi.nlm.nih.gov/pubmed/36799629
http://dx.doi.org/10.1158/1078-0432.CCR-22-3722

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