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Prognosis of cancer survivors: estimation based on differential equations

We present a method for estimating several prognosis parameters for cancer survivors. The method utilizes the fact that these parameters solve differential equations driven by cumulative hazards. By expressing the parameters as solutions to differential equations, we develop generic estimators that...

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Detalles Bibliográficos
Autores principales: Ryalen, Pål C, Møller, Bjørn, Laache, Christoffer H, Stensrud, Mats J, Røysland, Kjetil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102890/
https://www.ncbi.nlm.nih.gov/pubmed/34557893
http://dx.doi.org/10.1093/biostatistics/kxab009
Descripción
Sumario:We present a method for estimating several prognosis parameters for cancer survivors. The method utilizes the fact that these parameters solve differential equations driven by cumulative hazards. By expressing the parameters as solutions to differential equations, we develop generic estimators that are easy to implement with standard statistical software. We explicitly describe the estimators for prognosis parameters that are often employed in practice, but also for parameters that, to our knowledge, have not been used to evaluate prognosis. We then apply these parameters to assess the prognosis of five common cancers in Norway.