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Prognosis of cancer survivors: estimation based on differential equations
We present a method for estimating several prognosis parameters for cancer survivors. The method utilizes the fact that these parameters solve differential equations driven by cumulative hazards. By expressing the parameters as solutions to differential equations, we develop generic estimators that...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102890/ https://www.ncbi.nlm.nih.gov/pubmed/34557893 http://dx.doi.org/10.1093/biostatistics/kxab009 |
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author | Ryalen, Pål C Møller, Bjørn Laache, Christoffer H Stensrud, Mats J Røysland, Kjetil |
author_facet | Ryalen, Pål C Møller, Bjørn Laache, Christoffer H Stensrud, Mats J Røysland, Kjetil |
author_sort | Ryalen, Pål C |
collection | PubMed |
description | We present a method for estimating several prognosis parameters for cancer survivors. The method utilizes the fact that these parameters solve differential equations driven by cumulative hazards. By expressing the parameters as solutions to differential equations, we develop generic estimators that are easy to implement with standard statistical software. We explicitly describe the estimators for prognosis parameters that are often employed in practice, but also for parameters that, to our knowledge, have not been used to evaluate prognosis. We then apply these parameters to assess the prognosis of five common cancers in Norway. |
format | Online Article Text |
id | pubmed-10102890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-101028902023-04-15 Prognosis of cancer survivors: estimation based on differential equations Ryalen, Pål C Møller, Bjørn Laache, Christoffer H Stensrud, Mats J Røysland, Kjetil Biostatistics Article We present a method for estimating several prognosis parameters for cancer survivors. The method utilizes the fact that these parameters solve differential equations driven by cumulative hazards. By expressing the parameters as solutions to differential equations, we develop generic estimators that are easy to implement with standard statistical software. We explicitly describe the estimators for prognosis parameters that are often employed in practice, but also for parameters that, to our knowledge, have not been used to evaluate prognosis. We then apply these parameters to assess the prognosis of five common cancers in Norway. Oxford University Press 2021-09-24 /pmc/articles/PMC10102890/ /pubmed/34557893 http://dx.doi.org/10.1093/biostatistics/kxab009 Text en © The Author 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Ryalen, Pål C Møller, Bjørn Laache, Christoffer H Stensrud, Mats J Røysland, Kjetil Prognosis of cancer survivors: estimation based on differential equations |
title | Prognosis of cancer survivors: estimation based on differential equations |
title_full | Prognosis of cancer survivors: estimation based on differential equations |
title_fullStr | Prognosis of cancer survivors: estimation based on differential equations |
title_full_unstemmed | Prognosis of cancer survivors: estimation based on differential equations |
title_short | Prognosis of cancer survivors: estimation based on differential equations |
title_sort | prognosis of cancer survivors: estimation based on differential equations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102890/ https://www.ncbi.nlm.nih.gov/pubmed/34557893 http://dx.doi.org/10.1093/biostatistics/kxab009 |
work_keys_str_mv | AT ryalenpalc prognosisofcancersurvivorsestimationbasedondifferentialequations AT møllerbjørn prognosisofcancersurvivorsestimationbasedondifferentialequations AT laachechristofferh prognosisofcancersurvivorsestimationbasedondifferentialequations AT stensrudmatsj prognosisofcancersurvivorsestimationbasedondifferentialequations AT røyslandkjetil prognosisofcancersurvivorsestimationbasedondifferentialequations |