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Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study

BACKGROUND: The exact timing, causes, and circumstances of stillbirth and neonatal mortality in low- and middle-income countries (LMICs) remain poorly described, especially for antenatal stillbirths and deaths occurring at home. We aimed to provide reliable estimates of the incidence of stillbirth a...

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Autores principales: Rambliere, Lison, de Lauzanne, Agathe, Diouf, Jean-Baptiste, Zo, Andrianirina Zafitsara, Landau, Myriam, Herindrainy, Perlinot, Hivernaud, Delphine, Sarr, Fatoumata Diene, Sok, Touch, Vray, Muriel, Collard, Jean-Marc, Borand, Laurence, Delarocque-Astagneau, Elisabeth, Guillemot, Didier, Kermorvant-Duchemin, Elsa, Huynh, Bich-Tram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Global Health 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103017/
https://www.ncbi.nlm.nih.gov/pubmed/37057650
http://dx.doi.org/10.7189/jogh.13.04031
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author Rambliere, Lison
de Lauzanne, Agathe
Diouf, Jean-Baptiste
Zo, Andrianirina Zafitsara
Landau, Myriam
Herindrainy, Perlinot
Hivernaud, Delphine
Sarr, Fatoumata Diene
Sok, Touch
Vray, Muriel
Collard, Jean-Marc
Borand, Laurence
Delarocque-Astagneau, Elisabeth
Guillemot, Didier
Kermorvant-Duchemin, Elsa
Huynh, Bich-Tram
author_facet Rambliere, Lison
de Lauzanne, Agathe
Diouf, Jean-Baptiste
Zo, Andrianirina Zafitsara
Landau, Myriam
Herindrainy, Perlinot
Hivernaud, Delphine
Sarr, Fatoumata Diene
Sok, Touch
Vray, Muriel
Collard, Jean-Marc
Borand, Laurence
Delarocque-Astagneau, Elisabeth
Guillemot, Didier
Kermorvant-Duchemin, Elsa
Huynh, Bich-Tram
author_sort Rambliere, Lison
collection PubMed
description BACKGROUND: The exact timing, causes, and circumstances of stillbirth and neonatal mortality in low- and middle-income countries (LMICs) remain poorly described, especially for antenatal stillbirths and deaths occurring at home. We aimed to provide reliable estimates of the incidence of stillbirth and neonatal death in three LMICs (Madagascar, Cambodia and Senegal) and to identify their main causes and associated risk factors. METHODS: This study is based on data from an international, multicentric, prospective, longitudinal, community-based mother-infant cohort. We included pregnant mothers and prospectively followed up their children in the community. Stillbirths and deaths were systematically reported; information across healthcare settings was collected and verbal autopsies were performed to document the circumstances and timing of death. RESULTS: Among the 4436 pregnancies and 4334 live births, the peripartum period and the first day of life were the key periods of mortality. The estimated incidence of stillbirth was 11 per 1000 total births in Cambodia, 15 per 1000 in Madagascar, and 12 per 1000 in Senegal. We estimated neonatal mortality at 18 per 1000 live births in Cambodia, 24 per 1000 in Madagascar, and 23 per 1000 in Senegal. Based on ultrasound biometric data, 16.1% of infants in Madagascar were born prematurely, where 42% of deliveries and 33% of deaths occurred outside healthcare facilities. Risk factors associated with neonatal death were mainly related to delivery or to events that newborns faced during the first week of life. CONCLUSIONS: These findings underscore the immediate need to improve care for and monitoring of children at birth and during early life to decrease infant mortality. Surveillance of stillbirth and neonatal mortality and their causes should be improved to mitigate this burden in LMICs.
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spelling pubmed-101030172023-04-15 Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study Rambliere, Lison de Lauzanne, Agathe Diouf, Jean-Baptiste Zo, Andrianirina Zafitsara Landau, Myriam Herindrainy, Perlinot Hivernaud, Delphine Sarr, Fatoumata Diene Sok, Touch Vray, Muriel Collard, Jean-Marc Borand, Laurence Delarocque-Astagneau, Elisabeth Guillemot, Didier Kermorvant-Duchemin, Elsa Huynh, Bich-Tram J Glob Health Articles BACKGROUND: The exact timing, causes, and circumstances of stillbirth and neonatal mortality in low- and middle-income countries (LMICs) remain poorly described, especially for antenatal stillbirths and deaths occurring at home. We aimed to provide reliable estimates of the incidence of stillbirth and neonatal death in three LMICs (Madagascar, Cambodia and Senegal) and to identify their main causes and associated risk factors. METHODS: This study is based on data from an international, multicentric, prospective, longitudinal, community-based mother-infant cohort. We included pregnant mothers and prospectively followed up their children in the community. Stillbirths and deaths were systematically reported; information across healthcare settings was collected and verbal autopsies were performed to document the circumstances and timing of death. RESULTS: Among the 4436 pregnancies and 4334 live births, the peripartum period and the first day of life were the key periods of mortality. The estimated incidence of stillbirth was 11 per 1000 total births in Cambodia, 15 per 1000 in Madagascar, and 12 per 1000 in Senegal. We estimated neonatal mortality at 18 per 1000 live births in Cambodia, 24 per 1000 in Madagascar, and 23 per 1000 in Senegal. Based on ultrasound biometric data, 16.1% of infants in Madagascar were born prematurely, where 42% of deliveries and 33% of deaths occurred outside healthcare facilities. Risk factors associated with neonatal death were mainly related to delivery or to events that newborns faced during the first week of life. CONCLUSIONS: These findings underscore the immediate need to improve care for and monitoring of children at birth and during early life to decrease infant mortality. Surveillance of stillbirth and neonatal mortality and their causes should be improved to mitigate this burden in LMICs. International Society of Global Health 2023-04-14 /pmc/articles/PMC10103017/ /pubmed/37057650 http://dx.doi.org/10.7189/jogh.13.04031 Text en Copyright © 2023 by the Journal of Global Health. All rights reserved. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Articles
Rambliere, Lison
de Lauzanne, Agathe
Diouf, Jean-Baptiste
Zo, Andrianirina Zafitsara
Landau, Myriam
Herindrainy, Perlinot
Hivernaud, Delphine
Sarr, Fatoumata Diene
Sok, Touch
Vray, Muriel
Collard, Jean-Marc
Borand, Laurence
Delarocque-Astagneau, Elisabeth
Guillemot, Didier
Kermorvant-Duchemin, Elsa
Huynh, Bich-Tram
Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study
title Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study
title_full Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study
title_fullStr Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study
title_full_unstemmed Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study
title_short Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study
title_sort stillbirths and neonatal mortality in lmics: a community-based mother-infant cohort study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103017/
https://www.ncbi.nlm.nih.gov/pubmed/37057650
http://dx.doi.org/10.7189/jogh.13.04031
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