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Site-Specific Covalent Labeling of DNA Substrates by an RNA Transglycosylase

[Image: see text] Bacterial tRNA guanine transglycosylases (TGTs) catalyze the exchange of guanine for the 7-deazaguanine queuine precursor, prequeuosine1 (preQ1). While the native nucleic acid substrate for bacterial TGTs is the anticodon loop of queuine-cognate tRNAs, the minimum recognition seque...

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Detalles Bibliográficos
Autores principales: Tota, Ember M., Devaraj, Neal K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103133/
https://www.ncbi.nlm.nih.gov/pubmed/36988146
http://dx.doi.org/10.1021/jacs.3c00861