Uncovering the Role of N-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry

[Image: see text] Interactions between the SARS-CoV-2 Spike protein and ACE2 are one of the most scrutinized reactions of our time. Yet, questions remain as to the impact of glycans on mediating ACE2 dimerization and downstream interactions with Spike. Here, we address these unanswered questions by...

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Detalles Bibliográficos
Autores principales: El-Baba, Tarick J., Lutomski, Corinne A., Burnap, Sean A., Bolla, Jani R., Baker, Lindsay A., Baldwin, Andrew J., Struwe, Weston B., Robinson, Carol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103161/
https://www.ncbi.nlm.nih.gov/pubmed/37000485
http://dx.doi.org/10.1021/jacs.3c00291

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