Integrating Hydrogen Deuterium Exchange–Mass Spectrometry with Molecular Simulations Enables Quantification of the Conformational Populations of the Sugar Transporter XylE

[Image: see text] A yet unresolved challenge in structural biology is to quantify the conformational states of proteins underpinning function. This challenge is particularly acute for membrane proteins owing to the difficulties in stabilizing them for in vitro studies. To address this challenge, we...

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Detalles Bibliográficos
Autores principales: Jia, Ruyu, Bradshaw, Richard T., Calvaresi, Valeria, Politis, Argyris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103171/
https://www.ncbi.nlm.nih.gov/pubmed/36976935
http://dx.doi.org/10.1021/jacs.2c06148

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