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Acinetobase: the comprehensive database and repository of Acinetobacter strains

Acinetobacter baumannii is one of the most problematic nosocomial pathogens that can efficiently thrive within hospital settings, mainly due to resistances toward antibiotics, desiccation, disinfectants, human serum and oxidative stress. Recently, increased resistance against last-resort antibiotics...

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Autores principales: Valcek, Adam, Collier, James, Botzki, Alexander, Van der Henst, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103187/
https://www.ncbi.nlm.nih.gov/pubmed/36412325
http://dx.doi.org/10.1093/database/baac099
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author Valcek, Adam
Collier, James
Botzki, Alexander
Van der Henst, Charles
author_facet Valcek, Adam
Collier, James
Botzki, Alexander
Van der Henst, Charles
author_sort Valcek, Adam
collection PubMed
description Acinetobacter baumannii is one of the most problematic nosocomial pathogens that can efficiently thrive within hospital settings, mainly due to resistances toward antibiotics, desiccation, disinfectants, human serum and oxidative stress. Recently, increased resistance against last-resort antibiotics earns this bacterium the highest priority concern classified by the Centers for Disease Control and Prevention and the World Health Organization. An obvious hallmark of this bacterium is the high heterogeneity observed among A. baumannii isolates, with a limited core genome. This feature complexifies the study of A. baumannii bacteria as an entity, subsequently reflected in a diversity of phenotypes of not only antimicrobial and environmental resistance but also virulence. A high degree of genome plasticity, along with the use of a limited subset of established strains, can lead to strain-specific observations, decreasing the global understanding of this pathogenic agent. Phenotypic variability of A. baumannii strains is easily observable such as with the macrocolony morphologies, in vitro and in vivo virulence, natural competence level, production of different capsular polysaccharide structures and cellular densities. Some strains encode several virulence factors, while others, including the established strains, lack key ones. The lack/excess of genes or specific physiological processes might interfere with in vivo and in vitro experiments, thus providing a limited impact on the global understanding of Acinetobacter bacteria. As an answer to the high heterogeneity among A. baumannii strains, we propose a first comprehensive database that includes the bacterial strains and the associated phenotypic and genetic data. This new repository, freely accessible to the entire scientific community, allows selecting the best bacterial isolate(s) related to any biological question, using an efficient and fast exchange platform. Database URL: https://acinetobase.vib.be/
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spelling pubmed-101031872023-04-15 Acinetobase: the comprehensive database and repository of Acinetobacter strains Valcek, Adam Collier, James Botzki, Alexander Van der Henst, Charles Database (Oxford) Original Article Acinetobacter baumannii is one of the most problematic nosocomial pathogens that can efficiently thrive within hospital settings, mainly due to resistances toward antibiotics, desiccation, disinfectants, human serum and oxidative stress. Recently, increased resistance against last-resort antibiotics earns this bacterium the highest priority concern classified by the Centers for Disease Control and Prevention and the World Health Organization. An obvious hallmark of this bacterium is the high heterogeneity observed among A. baumannii isolates, with a limited core genome. This feature complexifies the study of A. baumannii bacteria as an entity, subsequently reflected in a diversity of phenotypes of not only antimicrobial and environmental resistance but also virulence. A high degree of genome plasticity, along with the use of a limited subset of established strains, can lead to strain-specific observations, decreasing the global understanding of this pathogenic agent. Phenotypic variability of A. baumannii strains is easily observable such as with the macrocolony morphologies, in vitro and in vivo virulence, natural competence level, production of different capsular polysaccharide structures and cellular densities. Some strains encode several virulence factors, while others, including the established strains, lack key ones. The lack/excess of genes or specific physiological processes might interfere with in vivo and in vitro experiments, thus providing a limited impact on the global understanding of Acinetobacter bacteria. As an answer to the high heterogeneity among A. baumannii strains, we propose a first comprehensive database that includes the bacterial strains and the associated phenotypic and genetic data. This new repository, freely accessible to the entire scientific community, allows selecting the best bacterial isolate(s) related to any biological question, using an efficient and fast exchange platform. Database URL: https://acinetobase.vib.be/ Oxford University Press 2022-11-22 /pmc/articles/PMC10103187/ /pubmed/36412325 http://dx.doi.org/10.1093/database/baac099 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Valcek, Adam
Collier, James
Botzki, Alexander
Van der Henst, Charles
Acinetobase: the comprehensive database and repository of Acinetobacter strains
title Acinetobase: the comprehensive database and repository of Acinetobacter strains
title_full Acinetobase: the comprehensive database and repository of Acinetobacter strains
title_fullStr Acinetobase: the comprehensive database and repository of Acinetobacter strains
title_full_unstemmed Acinetobase: the comprehensive database and repository of Acinetobacter strains
title_short Acinetobase: the comprehensive database and repository of Acinetobacter strains
title_sort acinetobase: the comprehensive database and repository of acinetobacter strains
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103187/
https://www.ncbi.nlm.nih.gov/pubmed/36412325
http://dx.doi.org/10.1093/database/baac099
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