Local ocular safety of the subconjunctival injection of cetuximab in rabbits

BACKGROUND: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. METHODS: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar v...

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Autores principales: Aghaei, Hossein, Kheirkhah, Ahmad, Alizadeh, Ali Mohammad, Es’haghi, Acieh, Aliakbar-Navahi, Roshanak, Keikha, Zahra, Chaibakhsh, Samira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103399/
https://www.ncbi.nlm.nih.gov/pubmed/37055797
http://dx.doi.org/10.1186/s12886-023-02893-6
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author Aghaei, Hossein
Kheirkhah, Ahmad
Alizadeh, Ali Mohammad
Es’haghi, Acieh
Aliakbar-Navahi, Roshanak
Keikha, Zahra
Chaibakhsh, Samira
author_facet Aghaei, Hossein
Kheirkhah, Ahmad
Alizadeh, Ali Mohammad
Es’haghi, Acieh
Aliakbar-Navahi, Roshanak
Keikha, Zahra
Chaibakhsh, Samira
author_sort Aghaei, Hossein
collection PubMed
description BACKGROUND: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. METHODS: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining. RESULTS: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab. CONCLUSION: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.
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spelling pubmed-101033992023-04-15 Local ocular safety of the subconjunctival injection of cetuximab in rabbits Aghaei, Hossein Kheirkhah, Ahmad Alizadeh, Ali Mohammad Es’haghi, Acieh Aliakbar-Navahi, Roshanak Keikha, Zahra Chaibakhsh, Samira BMC Ophthalmol Research Article BACKGROUND: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. METHODS: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining. RESULTS: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab. CONCLUSION: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe. BioMed Central 2023-04-13 /pmc/articles/PMC10103399/ /pubmed/37055797 http://dx.doi.org/10.1186/s12886-023-02893-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Aghaei, Hossein
Kheirkhah, Ahmad
Alizadeh, Ali Mohammad
Es’haghi, Acieh
Aliakbar-Navahi, Roshanak
Keikha, Zahra
Chaibakhsh, Samira
Local ocular safety of the subconjunctival injection of cetuximab in rabbits
title Local ocular safety of the subconjunctival injection of cetuximab in rabbits
title_full Local ocular safety of the subconjunctival injection of cetuximab in rabbits
title_fullStr Local ocular safety of the subconjunctival injection of cetuximab in rabbits
title_full_unstemmed Local ocular safety of the subconjunctival injection of cetuximab in rabbits
title_short Local ocular safety of the subconjunctival injection of cetuximab in rabbits
title_sort local ocular safety of the subconjunctival injection of cetuximab in rabbits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103399/
https://www.ncbi.nlm.nih.gov/pubmed/37055797
http://dx.doi.org/10.1186/s12886-023-02893-6
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