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Mirtazapine-induced neutropenic sepsis in an older person: a case report

BACKGROUND: Mirtazapine is a frequently prescribed psychotropic drug for depression in older age. It is considered safe and has a side-effect profile uniquely favorable to an older person affected by reduced appetite, difficulty maintaining body weight, or insomnia. However, it is largely unknown th...

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Autores principales: Maidwell-Smith, Alice, Kirk, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103480/
https://www.ncbi.nlm.nih.gov/pubmed/37055872
http://dx.doi.org/10.1186/s13256-023-03881-6
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author Maidwell-Smith, Alice
Kirk, Charlotte
author_facet Maidwell-Smith, Alice
Kirk, Charlotte
author_sort Maidwell-Smith, Alice
collection PubMed
description BACKGROUND: Mirtazapine is a frequently prescribed psychotropic drug for depression in older age. It is considered safe and has a side-effect profile uniquely favorable to an older person affected by reduced appetite, difficulty maintaining body weight, or insomnia. However, it is largely unknown that mirtazapine can cause a dangerous decline in neutrophil count. CASE PRESENTATION: We present a case of mirtazapine-induced severe neutropenia in a 91-year-old white British woman requiring drug withdrawal and granulocyte-colony stimulating factor administration. CONCLUSION: This case is of significance because mirtazapine is regarded as a safe, and often preferable, antidepressant in older age. However, this case demonstrates a rare, life-threatening side effect of mirtazapine and calls for greater pharmacovigilance when prescribing it. There is no previous report of mirtazapine-induced neutropenia requiring drug withdrawal and granulocyte-colony stimulating factor administration in an older person.
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spelling pubmed-101034802023-04-15 Mirtazapine-induced neutropenic sepsis in an older person: a case report Maidwell-Smith, Alice Kirk, Charlotte J Med Case Rep Case Report BACKGROUND: Mirtazapine is a frequently prescribed psychotropic drug for depression in older age. It is considered safe and has a side-effect profile uniquely favorable to an older person affected by reduced appetite, difficulty maintaining body weight, or insomnia. However, it is largely unknown that mirtazapine can cause a dangerous decline in neutrophil count. CASE PRESENTATION: We present a case of mirtazapine-induced severe neutropenia in a 91-year-old white British woman requiring drug withdrawal and granulocyte-colony stimulating factor administration. CONCLUSION: This case is of significance because mirtazapine is regarded as a safe, and often preferable, antidepressant in older age. However, this case demonstrates a rare, life-threatening side effect of mirtazapine and calls for greater pharmacovigilance when prescribing it. There is no previous report of mirtazapine-induced neutropenia requiring drug withdrawal and granulocyte-colony stimulating factor administration in an older person. BioMed Central 2023-04-14 /pmc/articles/PMC10103480/ /pubmed/37055872 http://dx.doi.org/10.1186/s13256-023-03881-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Maidwell-Smith, Alice
Kirk, Charlotte
Mirtazapine-induced neutropenic sepsis in an older person: a case report
title Mirtazapine-induced neutropenic sepsis in an older person: a case report
title_full Mirtazapine-induced neutropenic sepsis in an older person: a case report
title_fullStr Mirtazapine-induced neutropenic sepsis in an older person: a case report
title_full_unstemmed Mirtazapine-induced neutropenic sepsis in an older person: a case report
title_short Mirtazapine-induced neutropenic sepsis in an older person: a case report
title_sort mirtazapine-induced neutropenic sepsis in an older person: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103480/
https://www.ncbi.nlm.nih.gov/pubmed/37055872
http://dx.doi.org/10.1186/s13256-023-03881-6
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