Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation

BACKGROUND: Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer’s disease (AD). However, the sensitivity of cholinergic neurons to AD-like tau accumulation and strategies to ameliorate tau-disrupted spatial memory in terms of neura...

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Detalles Bibliográficos
Autores principales: Wu, Dongqin, Yu, Nana, Gao, Yang, Xiong, Rui, Liu, Luping, Lei, Huiyang, Jin, Sen, Liu, Jiale, Liu, Yingzhou, Xie, Jiazhao, Liu, Enjie, Zhou, Qiuzhi, Liu, Yanchao, Li, Shihong, Wei, Linyu, Lv, Jingru, Yu, Huilin, Zeng, Wenbo, Zhou, Qiang, Xu, Fuqiang, Luo, Min-Hua, Zhang, Yao, Yang, Ying, Wang, Jian-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103508/
https://www.ncbi.nlm.nih.gov/pubmed/37060096
http://dx.doi.org/10.1186/s13024-023-00614-7

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