Cargando…

Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts

Nano-catalysts are of special character for the synthesis of organic molecules with high efficiency, and exceptional physicochemical properties. The objective of this study was to present an overview of the literature reports concerning the synthetic strategies supported by nano-catalysts and the bi...

Descripción completa

Detalles Bibliográficos
Autores principales: Hammouda, Mohamed M., Rashed, Marwa M., Elattar, Khaled M., Osman, Amany M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103583/
https://www.ncbi.nlm.nih.gov/pubmed/37063723
http://dx.doi.org/10.1039/d3ra00922j
_version_ 1785025883375927296
author Hammouda, Mohamed M.
Rashed, Marwa M.
Elattar, Khaled M.
Osman, Amany M. A.
author_facet Hammouda, Mohamed M.
Rashed, Marwa M.
Elattar, Khaled M.
Osman, Amany M. A.
author_sort Hammouda, Mohamed M.
collection PubMed
description Nano-catalysts are of special character for the synthesis of organic molecules with high efficiency, and exceptional physicochemical properties. The objective of this study was to present an overview of the literature reports concerning the synthetic strategies supported by nano-catalysts and the biological features of heterocycle-integrated pyridopyrimidine scaffolds. The basic topics include the strategies that were adopted to prepare pyrido[2,3-d]pyrimidines and pyrido[1,2-a]pyrimidines. The synthesis of pyrido[2,3-d]pyrimidines was attained through two-, three-, or four-component reactions. The synthesis of spirocyclic systems, including spiro[indoline-pyridopyrimidine] derivatives and arylation reactions, was investigated. The anticipated mechanisms of the diverse target products, in addition to the preparation of the nanocatalysts, were scrutinized. The privileged antimicrobial characteristics, challenges, literature overview, and future prospectives were consistently investigated.
format Online
Article
Text
id pubmed-10103583
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-101035832023-04-15 Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts Hammouda, Mohamed M. Rashed, Marwa M. Elattar, Khaled M. Osman, Amany M. A. RSC Adv Chemistry Nano-catalysts are of special character for the synthesis of organic molecules with high efficiency, and exceptional physicochemical properties. The objective of this study was to present an overview of the literature reports concerning the synthetic strategies supported by nano-catalysts and the biological features of heterocycle-integrated pyridopyrimidine scaffolds. The basic topics include the strategies that were adopted to prepare pyrido[2,3-d]pyrimidines and pyrido[1,2-a]pyrimidines. The synthesis of pyrido[2,3-d]pyrimidines was attained through two-, three-, or four-component reactions. The synthesis of spirocyclic systems, including spiro[indoline-pyridopyrimidine] derivatives and arylation reactions, was investigated. The anticipated mechanisms of the diverse target products, in addition to the preparation of the nanocatalysts, were scrutinized. The privileged antimicrobial characteristics, challenges, literature overview, and future prospectives were consistently investigated. The Royal Society of Chemistry 2023-04-14 /pmc/articles/PMC10103583/ /pubmed/37063723 http://dx.doi.org/10.1039/d3ra00922j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Hammouda, Mohamed M.
Rashed, Marwa M.
Elattar, Khaled M.
Osman, Amany M. A.
Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts
title Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts
title_full Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts
title_fullStr Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts
title_full_unstemmed Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts
title_short Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts
title_sort synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103583/
https://www.ncbi.nlm.nih.gov/pubmed/37063723
http://dx.doi.org/10.1039/d3ra00922j
work_keys_str_mv AT hammoudamohamedm syntheticstrategiesofheterocycleintegratedpyridopyrimidinescaffoldssupportedbynanocatalysts
AT rashedmarwam syntheticstrategiesofheterocycleintegratedpyridopyrimidinescaffoldssupportedbynanocatalysts
AT elattarkhaledm syntheticstrategiesofheterocycleintegratedpyridopyrimidinescaffoldssupportedbynanocatalysts
AT osmanamanyma syntheticstrategiesofheterocycleintegratedpyridopyrimidinescaffoldssupportedbynanocatalysts