Virus update for the M2 “mac-in-touch”

While HIV-1 infection of macrophages plays a major role in viral persistence and pathogenesis, how HIV-1 transfers from infected T cells to macrophages remains elusive. In this issue, Mascarau et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202205103) demonstrate how macrophage polarization...

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Detalles Bibliográficos
Autor principal: Naghavi, Mojgan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103641/
https://www.ncbi.nlm.nih.gov/pubmed/37043190
http://dx.doi.org/10.1083/jcb.202303016
Descripción
Sumario:While HIV-1 infection of macrophages plays a major role in viral persistence and pathogenesis, how HIV-1 transfers from infected T cells to macrophages remains elusive. In this issue, Mascarau et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202205103) demonstrate how macrophage polarization drives their ability to fuse with HIV-1 infected T cells via the CD81/RhoA-ROCK/Myosin axis.

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