Retinal Vascular Oxygen Saturation in Adults With Anisometropia

PURPOSE: This study aimed to examine the differences of retinal oxygen saturation between the paired eyes in anisometropia and to further explore the relation between retinal oxygenation and myopia. METHODS: This was an observational cross-sectional study, with 124 adults with anisometropia included. According to the interocular differences in spherical equivalent (SE), individuals with a difference ≥3.0 D belonged to the ΔSE ≥ 3.0 D group, and those with a difference ≥1.5 D and <3.0 D belonged to the ΔSE <3.0 D group. The ΔSE ≥ 3.0 D group contained 61, and the ΔSE < 3.0 D group contained 64. All were performed examinations of retinal oximetry, SE, axial length (AL), intraocular pressure, central corneal thickness and average keratometry. RESULTS: The median SE and AL were −5.06 (−7.22 ∼ −3.41) D and 25.54 (24.73 ∼ 26.62) mm in the “ΔSE < 3 D” group and −4.25 (−6.88 ∼ −2.09) D and 25.52 (24.49 ∼ 26.45) mm in the other group. The retinal arterial oxygen saturation (SaO(2)) was 93.97% ± 1.26% in the less myopic eyes and 93.18% ± 1.53% (P < 0.001) in the more myopic eyes. In multivariate analyses, SE and AL were both significantly associated with the SaO(2). CONCLUSIONS: The SaO(2) between anisometropic myopic eyes was different, and it was associated with SE and AL. TRANSLATIONAL RELEVANCE: This study demonstrates a relationship between myopia and retinal vascular oxygenation through a novel retinal oximeter.