Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer

ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been made in identifying specific phenotypic outcomes f...

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Detalles Bibliográficos
Autores principales: Fennell, Emily M. J., Aponte-Collazo, Lucas J., Pathmasiri, Wimal, Rushing, Blake R., Barker, Natalie K., Partridge, Megan C., Li, Yuan-Yuan, White, Cody A., Greer, Yoshimi E., Herring, Laura E., Lipkowitz, Stanley, Sumner, Susan C. J., Iwanowicz, Edwin J., Graves, Lee M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103842/
https://www.ncbi.nlm.nih.gov/pubmed/37063293
http://dx.doi.org/10.3389/fphar.2023.1136317

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