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The Osseous Pathology of Purpura Fulminans in a Two-Year-Old Child: A Case Report

Purpura fulminans (PF) is a severe clinical manifestation of Neisseria meningitides infection that is associated with high mortality rates in children. Survivors are frequently left with debilitating musculoskeletal sequelae. There is a paucity of reports on the musculoskeletal pathology of purpura...

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Autores principales: Mohd-Razali, S, Ahmad-Affandi, K, Ibrahim, S, Abdul-Rashid, AH, Abdul-Shukor, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Malaysian Orthopaedic Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103933/
https://www.ncbi.nlm.nih.gov/pubmed/37064633
http://dx.doi.org/10.5704/MOJ.2303.021
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author Mohd-Razali, S
Ahmad-Affandi, K
Ibrahim, S
Abdul-Rashid, AH
Abdul-Shukor, N
author_facet Mohd-Razali, S
Ahmad-Affandi, K
Ibrahim, S
Abdul-Rashid, AH
Abdul-Shukor, N
author_sort Mohd-Razali, S
collection PubMed
description Purpura fulminans (PF) is a severe clinical manifestation of Neisseria meningitides infection that is associated with high mortality rates in children. Survivors are frequently left with debilitating musculoskeletal sequelae. There is a paucity of reports on the musculoskeletal pathology of purpura fulminans. We report on a 2-year-old boy with purpura fulminans due to meningococcemia. The child developed distal gangrene in both the upper and lower limbs. Amputations were done for both lower limbs. Histological examination of the amputated specimens showed an inflammatory process and features of osteonecrosis. The latest follow-up at the age of 6 years showed a right knee valgus due to asymmetrical growth arrest of the proximal tibia. PF and its complications are challenging to treat and may require a multidisciplinary approach to improve patient’s functional ability.
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spelling pubmed-101039332023-04-15 The Osseous Pathology of Purpura Fulminans in a Two-Year-Old Child: A Case Report Mohd-Razali, S Ahmad-Affandi, K Ibrahim, S Abdul-Rashid, AH Abdul-Shukor, N Malays Orthop J Case Report Purpura fulminans (PF) is a severe clinical manifestation of Neisseria meningitides infection that is associated with high mortality rates in children. Survivors are frequently left with debilitating musculoskeletal sequelae. There is a paucity of reports on the musculoskeletal pathology of purpura fulminans. We report on a 2-year-old boy with purpura fulminans due to meningococcemia. The child developed distal gangrene in both the upper and lower limbs. Amputations were done for both lower limbs. Histological examination of the amputated specimens showed an inflammatory process and features of osteonecrosis. The latest follow-up at the age of 6 years showed a right knee valgus due to asymmetrical growth arrest of the proximal tibia. PF and its complications are challenging to treat and may require a multidisciplinary approach to improve patient’s functional ability. Malaysian Orthopaedic Association 2023-03 /pmc/articles/PMC10103933/ /pubmed/37064633 http://dx.doi.org/10.5704/MOJ.2303.021 Text en © 2023 Malaysian Orthopaedic Association (MOA). All Rights Reserved https://creativecommons.org/licenses/by/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
spellingShingle Case Report
Mohd-Razali, S
Ahmad-Affandi, K
Ibrahim, S
Abdul-Rashid, AH
Abdul-Shukor, N
The Osseous Pathology of Purpura Fulminans in a Two-Year-Old Child: A Case Report
title The Osseous Pathology of Purpura Fulminans in a Two-Year-Old Child: A Case Report
title_full The Osseous Pathology of Purpura Fulminans in a Two-Year-Old Child: A Case Report
title_fullStr The Osseous Pathology of Purpura Fulminans in a Two-Year-Old Child: A Case Report
title_full_unstemmed The Osseous Pathology of Purpura Fulminans in a Two-Year-Old Child: A Case Report
title_short The Osseous Pathology of Purpura Fulminans in a Two-Year-Old Child: A Case Report
title_sort osseous pathology of purpura fulminans in a two-year-old child: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103933/
https://www.ncbi.nlm.nih.gov/pubmed/37064633
http://dx.doi.org/10.5704/MOJ.2303.021
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