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GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus)
There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative pr...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103962/ https://www.ncbi.nlm.nih.gov/pubmed/37066261 http://dx.doi.org/10.1101/2023.04.03.535372 |
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author | Nguyen, Elizabeth Dong Fard, Vahid Nikoonejad Kim, Bernard Y. Collins, Sarah Galey, Miranda Nelson, Branden R. Wakenight, Paul Gable, Simone M. McKenna, Aaron Bammler, Theo K. MacDonald, Jim Okamura, Daryl M. Shendure, Jay Beier, David R. Ramirez, Jan Marino Majesky, Mark W. Millen, Kathleen J. Tollis, Marc Miller, Danny E. |
author_facet | Nguyen, Elizabeth Dong Fard, Vahid Nikoonejad Kim, Bernard Y. Collins, Sarah Galey, Miranda Nelson, Branden R. Wakenight, Paul Gable, Simone M. McKenna, Aaron Bammler, Theo K. MacDonald, Jim Okamura, Daryl M. Shendure, Jay Beier, David R. Ramirez, Jan Marino Majesky, Mark W. Millen, Kathleen J. Tollis, Marc Miller, Danny E. |
author_sort | Nguyen, Elizabeth Dong |
collection | PubMed |
description | There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome for A. cahirinus generated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from four different tissues. Our genome is of higher contiguity and quality than previously reported genomes from this species and will facilitate ongoing efforts to better understand the regenerative properties of this organism. |
format | Online Article Text |
id | pubmed-10103962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-101039622023-04-15 GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus) Nguyen, Elizabeth Dong Fard, Vahid Nikoonejad Kim, Bernard Y. Collins, Sarah Galey, Miranda Nelson, Branden R. Wakenight, Paul Gable, Simone M. McKenna, Aaron Bammler, Theo K. MacDonald, Jim Okamura, Daryl M. Shendure, Jay Beier, David R. Ramirez, Jan Marino Majesky, Mark W. Millen, Kathleen J. Tollis, Marc Miller, Danny E. bioRxiv Article There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome for A. cahirinus generated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from four different tissues. Our genome is of higher contiguity and quality than previously reported genomes from this species and will facilitate ongoing efforts to better understand the regenerative properties of this organism. Cold Spring Harbor Laboratory 2023-04-05 /pmc/articles/PMC10103962/ /pubmed/37066261 http://dx.doi.org/10.1101/2023.04.03.535372 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Nguyen, Elizabeth Dong Fard, Vahid Nikoonejad Kim, Bernard Y. Collins, Sarah Galey, Miranda Nelson, Branden R. Wakenight, Paul Gable, Simone M. McKenna, Aaron Bammler, Theo K. MacDonald, Jim Okamura, Daryl M. Shendure, Jay Beier, David R. Ramirez, Jan Marino Majesky, Mark W. Millen, Kathleen J. Tollis, Marc Miller, Danny E. GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus) |
title | GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus) |
title_full | GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus) |
title_fullStr | GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus) |
title_full_unstemmed | GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus) |
title_short | GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus) |
title_sort | genome report: chromosome-scale genome assembly of the african spiny mouse (acomys cahirinus) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103962/ https://www.ncbi.nlm.nih.gov/pubmed/37066261 http://dx.doi.org/10.1101/2023.04.03.535372 |
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