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DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an essential enzyme in the de novo pyrimidine biosynthesis pathway t...

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Detalles Bibliográficos
Autores principales:	Mullen, Nicholas J., Shukla, Surendra K., Thakur, Ravi, Kollala, Sai Sundeep, Wang, Dezhen, Chaika, Nina, LaBreck, Drew A., Mallareddy, Jayapal Reddy, Price, David H., Natarajan, Amarnath, Mehla, Kamiya, Sykes, David B., Hollingsworth, Michael A., Singh, Pankaj K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103971/ https://www.ncbi.nlm.nih.gov/pubmed/37066260 http://dx.doi.org/10.1101/2023.04.03.535399

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