Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

Chromosomal instability (CIN), a state in which cells undergo mitotic aberrations that generate chromosome copy number variations, generates aneuploidy and is thought to drive cancer evolution. Although associated with poor prognosis and reduced immune response, CIN generates aneuploidy-induced stre...

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Detalles Bibliográficos
Autores principales: Hayes, Brandon H., Wang, Mai, Zhu, Hui, Phan, Steven H., Andrechak, Jason C., Chang, Alexander H., Dooling, Lawrence J., Tobin, Michael P., Marchena, Tristan, Discher, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103980/
https://www.ncbi.nlm.nih.gov/pubmed/37066426
http://dx.doi.org/10.1101/2023.04.02.535275

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