Deep mutational scanning highlights a new role for cytosolic regions in Hrd1 function

Misfolded endoplasmic reticulum proteins are degraded through a process called endoplasmic reticulum associated degradation (ERAD). Soluble, lumenal ERAD targets are recognized, retrotranslocated across the ER membrane, ubiquitinated, extracted from the membrane, and degraded by the proteasome using...

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Detalles Bibliográficos
Autores principales: Peterson, Brian G., Hwang, Jiwon, Russ, Jennifer E., Schroeder, Jeremy, Freddolino, Peter L., Baldridge, Ryan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103981/
https://www.ncbi.nlm.nih.gov/pubmed/37066402
http://dx.doi.org/10.1101/2023.04.03.535444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103981/
https://www.ncbi.nlm.nih.gov/pubmed/37066402
http://dx.doi.org/10.1101/2023.04.03.535444

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