Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development

RNA isoforms influence cell identity and function. Until recently, technological limitations prevented a genome-wide appraisal of isoform influence on cell identity in various parts of the brain. Using enhanced long-read single-cell isoform sequencing, we comprehensively analyze RNA isoforms in mult...

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Detalles Bibliográficos
Autores principales: Joglekar, Anoushka, Hu, Wen, Zhang, Bei, Narykov, Oleksandr, Diekhans, Mark, Balacco, Jennifer, Ndhlovu, Lishomwa C, Milner, Teresa A, Fedrigo, Olivier, Jarvis, Erich D, Sheynkman, Gloria, Korkin, Dmitry, Ross, M. Elizabeth, Tilgner, Hagen U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103983/
https://www.ncbi.nlm.nih.gov/pubmed/37066387
http://dx.doi.org/10.1101/2023.04.02.535281

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