Mechanism of delayed cell death following simultaneous CRISPR-Cas9 targeting in pancreatic cancers

When we transduced pancreatic cancers with sgRNAs that targeted 2–16 target sites in the human genome, we found that increasing the number of CRISPR-Cas9 target sites produced greater cytotoxicity, with >99% growth inhibition observed by targeting only 12 sites. However, cell death was delayed by...

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Detalles Bibliográficos
Autores principales: Teh, Selina Shiqing K., Halper-Stromberg, Eitan, Morsberger, Laura, Bennett, Alexis, Bowland, Kirsten, Skaist, Alyza, Cai, Fidel, Liang, Hong, Hruban, Ralph H., Roberts, Nicholas J., Scharpf, Robert B., Zou, Ying S., Eshleman, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103988/
https://www.ncbi.nlm.nih.gov/pubmed/37066222
http://dx.doi.org/10.1101/2023.04.03.535384

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