Cargando…

Combination CDC-like kinase inhibition (CLK)/Dual-specificity tyrosine-regulated kinase (DYRK) and taxane therapy in CTNNB1-mutated endometrial cancer

SM08502 (cirtuvivint) is a novel pan CDC-like kinase (CLK) and Dual specificity tyrosine kinase (DYRK) inhibitor that targets mRNA splicing and is optimized for Wnt pathway inhibition. Previous evaluation of single agent CLK/DYRK inhibition (SM04690) demonstrated inhibition of tumor progression and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Corr, Bradley R, Moroney, Marisa R, Woodruff, Elizabeth, Watson, Zachary L, Jordan, Kimberly R., Danhorn, Thomas, Bailey, Courtney, Wolsky, Rebecca J, Bitler, Benjamin G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104048/ https://www.ncbi.nlm.nih.gov/pubmed/37066339 http://dx.doi.org/10.1101/2023.04.04.535570

Ejemplares similares

SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4
por: Tiek, Deanna, et al.
Publicado: (2023)

Pharmacophore and 3D-QSAR Characterization of 6-Arylquinazolin-4-amines as Cdc2-like Kinase 4 (Clk4) and Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A (Dyrk1A) Inhibitors
por: Pan, Yongmei, et al.
Publicado: (2013)

Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview
por: Lindberg, Mattias F., et al.
Publicado: (2021)

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases
por: Loaëc, Nadège, et al.
Publicado: (2017)

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
por: Uzor, Simon, et al.
Publicado: (2021)

Wnt Signaling in Gynecologic Malignancies
por: McMellen, Alexandra, et al.
Publicado: (2020)

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
por: Saldivia, Manuel, et al.
Publicado: (2020)

Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation
por: Bullock, Alex N., et al.
Publicado: (2009)

Clk/STY (cdc2-Like Kinase 1) and Akt Regulate Alternative Splicing and Adipogenesis in 3T3-L1 Pre-Adipocytes
por: Li, Pengfei, et al.
Publicado: (2013)

Clinical presentation of brain metastases from endometrial carcinoma: A case series
por: Moroney, Marisa R., et al.
Publicado: (2019)

Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members
por: Prak, Krisna, et al.
Publicado: (2015)

Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors
por: Schmitt, Christian, et al.
Publicado: (2014)

Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma
por: Uhl, Katie L., et al.
Publicado: (2018)

The DYRK-family kinase Pom1 phosphorylates the F-BAR protein Cdc15 to prevent division at cell poles
por: Ullal, Pranav, et al.
Publicado: (2015)

Retraction: The DYRK-family kinase Pom1 phosphorylates the F-BAR Cdc15 to prevent division at cell poles
por: Ullal, Pranav, et al.
Publicado: (2017)

DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division
por: Bhattacharjee, Rahul, et al.
Publicado: (2020)

The Role of CTNNB1 in Endometrial Cancer
por: Ledinek, Živa, et al.
Publicado: (2022)

Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A
por: Widowati, Esti Wahyu, et al.
Publicado: (2018)

Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases
por: Dao, Viet Hung, et al.
Publicado: (2021)

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
por: Dahal, Subha, et al.
Publicado: (2022)

Mirk/dyrk1B Kinase in Ovarian Cancer
por: Friedman, Eileen
Publicado: (2013)

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
por: Papenfuss, Marco, et al.
Publicado: (2022)

Adjuvant therapy of endometrial cancer: “taxane or not taxane, this is the question”
por: Lorusso, Vito, et al.
Publicado: (2019)

Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core
por: Ţînţaş, Mihaela-Liliana, et al.
Publicado: (2022)

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition
por: Soundararajan, Meera, et al.
Publicado: (2013)

Targeting LIM kinases in taxane resistant tumors
por: Prunier, Chloé, et al.
Publicado: (2016)

Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases
por: Correa-Sáez, Alejandro, et al.
Publicado: (2020)

Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control
por: Singh, Rajeev, et al.
Publicado: (2017)

The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities
por: Boni, Jacopo, et al.
Publicado: (2020)

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
por: Wong, Raymond, et al.
Publicado: (2011)

Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases
por: Brahmaiah, Dabbugoddu, et al.
Publicado: (2022)

Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer
por: Yan, Haiyan, et al.
Publicado: (2016)

Discovery of new Cdc2-like kinase 4 (CLK4) inhibitors via pharmacophore exploration combined with flexible docking-based ligand/receptor contact fingerprints and machine learning
por: Al-Tawil, Mai Fayiz, et al.
Publicado: (2022)

Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK
por: Clayton, Natasha S., et al.
Publicado: (2022)

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ
por: Sonamoto, Rie, et al.
Publicado: (2015)

Inhibition of the SR Protein-Phosphorylating CLK Kinases of Plasmodium falciparum Impairs Blood Stage Replication and Malaria Transmission
por: Kern, Selina, et al.
Publicado: (2014)

Inhibitors of CLK Protein Kinases Suppress Cell Growth and Induce Apoptosis by Modulating Pre-mRNA Splicing
por: Araki, Shinsuke, et al.
Publicado: (2015)

Controlling clots with Clk1
por: Williams, Ruth
Publicado: (2006)

Sensitizing endometrial cancer to ionizing radiation by multi-tyrosine kinase inhibition
por: Wang, Edina, et al.
Publicado: (2019)

Protein kinase DYRK2 is an E3-ligase specific molecular assembler
por: Maddika, Subbareddy, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_1pu0ievvu8fgjuo64lkkg1vkos