Single cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveals heterogeneity of endothelial subtype and response to activating perturbations

OBJECTIVE: Endothelial cells (ECs) are a major cell type in atherosclerosis progression, and heterogeneity in EC sub-phenotypes are becoming increasingly appreciated. Still, studies quantifying EC heterogeneity across whole transcriptomes and epigenomes in both in vitro and in vivo models are lackin...

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Detalles Bibliográficos
Autores principales: Adelus, Maria L., Ding, Jiacheng, Tran, Binh T., Conklin, Austin C., Golebiewski, Anna K., Stolze, Lindsey K., Whalen, Michael B., Cusanovich, Darren A., Romanoski, Casey E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104082/
https://www.ncbi.nlm.nih.gov/pubmed/37066416
http://dx.doi.org/10.1101/2023.04.03.535495

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