Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors

Attenuating aberrant transcriptional circuits holds great promise for the treatment of numerous diseases, including cancer. However, development of transcriptional inhibitors is hampered by the lack of a generally accepted functional cellular readout to characterize their target specificity and on-t...

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Detalles Bibliográficos
Autores principales: Harada, Taku, Perez, Monika W., Kalfon, Jérémie, Braes, Flora Dievenich, Batley, Rashad, Eagle, Kenneth, Nabet, Behnam, Leifer, Becky, Kruell, Jasmin, Paralkar, Vikram R., Stegmaier, Kimberly, Koehler, Angela N., Orkin, Stuart H., Pimkin, Maxim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104119/
https://www.ncbi.nlm.nih.gov/pubmed/37066194
http://dx.doi.org/10.1101/2023.04.07.536032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104119/
https://www.ncbi.nlm.nih.gov/pubmed/37066194
http://dx.doi.org/10.1101/2023.04.07.536032

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