Progranulin inhibits phospholipase sPLA2-IIA to control neuroinflammation

Mutations in the granulin (GRN) gene, resulting in haploinsufficiency of the progranulin (PGRN) protein, are a leading cause of frontotemporal lobar degeneration (FTLD) and PGRN polymorphisms are associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD). PGRN is a key regulator of microg...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Huan, Yang, Cha, Nana, Alissa L., Seeley, William W., Smolka, Marcus, Hu, Fenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104136/
https://www.ncbi.nlm.nih.gov/pubmed/37066328
http://dx.doi.org/10.1101/2023.04.06.535844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104136/
https://www.ncbi.nlm.nih.gov/pubmed/37066328
http://dx.doi.org/10.1101/2023.04.06.535844

Ejemplares similares